KIF3B Antibody (G-5): sc-514165

KIF3B Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIF3B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-KIF3B antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIF3B is a member of the kinesin family, which comprises a diverse group of microtubule-dependent motor proteins that play vital roles in intracellular transport, organelle distribution, and cellular processes such as cell division. Specifically, KIF3B is crucial for the anterograde transport of membrane-bound organelles in neurons and melanosomes, as well as the transport of protein complexes within cilia and flagella, which are essential for their proper morphogenesis. KIF3B is encoded by a gene located on chromosome 20 and consists of 747 amino acids, exhibiting ubiquitous expression across various tissues. Notably, KIF3B is integral to left-right determination during embryonic development, functioning through a mechanism that establishes a morphogen gradient along the left-right axis in the embryonic node. This gradient is critical for the correct positioning of internal organs, highlighting KIF3B′s importance in developmental biology and potential implications in understanding congenital disorders related to left-right asymmetry.

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KIF3B Antibody (G-5) References:

1. Molecular motors and their role in membrane traffic.  |  Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
2. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
3. Stirring up development with the heterotrimeric kinesin KIF3.  |  Hirokawa, N. 2000. Traffic. 1: 29-34. PMID: 11208056
4. Kinesin-II, the heteromeric kinesin.  |  Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
5. Functional analysis of mouse kinesin motor Kif3C.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 5306-11. PMID: 11463814
6. Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation.  |  Huang, X., et al. 2014. Dig Dis Sci. 59: 795-806. PMID: 24368420
7. KIF3B Promotes the Proliferation of Pancreatic Cancer.  |  Liu, ZH., et al. 2019. Cancer Biother Radiopharm. 34: 355-361. PMID: 31157987
8. Research progress on KIF3B and related diseases.  |  Zhou, L., et al. 2019. Ann Transl Med. 7: 492. PMID: 31700928
9. Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.  |  Cogné, B., et al. 2020. Am J Hum Genet. 106: 893-904. PMID: 32386558
10. YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway.  |  Zheng, C., et al. 2023. Cell Death Dis. 14: 806. PMID: 38065955
11. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.  |  Yamazaki, H., et al. 1995. J Cell Biol. 130: 1387-99. PMID: 7559760
12. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.  |  Nonaka, S., et al. 1998. Cell. 95: 829-37. PMID: 9865700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF3B Antibody (G-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF3B Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF3B Antibody (G-5) Specifications

Alternate Product Name: KIF3B

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 666-725

Epitope Target: KIF3B

Epitope Species: human

Product Reactivity/Detection: KIF3B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for KIF3B Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin