KIF1B Antibody (E-12): sc-376246
- KIF1B Antibody (E-12) is a mouse monoclonal IgG1 κ KIF1B antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 964-1153 mapping at the C-terminus of KIF1B of human origin
- KIF1B Antibody (E-12) is recommended for detection of KIF1B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-KIF1B Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KIF1B Antibody (E-12) for WB and IHC(P) applications. These reagents are now offered in bundles with KIF1B Antibody (E-12) (see ordering information below).
KIF1B Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIF1B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-KIF1B antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIF1B is a vital member of the KIF1/Unc104 family of kinesin-like proteins, which are essential for the transport of mitochondria and synaptic vesicles along axons. KIF1B plays a crucial role in maintaining neuronal health by facilitating the distribution of organelles necessary for energy production and neurotransmitter release. KIF1B shows predominant expression in differentiated nerve cells, highlighting its importance in the nervous system. The human KIF1B gene is located on chromosome 1p36.2, and mutations in this gene can lead to defects in axonal transport, contributing to peripheral neuropathy. The mouse KIF1B gene produces an alternatively spliced transcript that results in two distinct isoforms, further underscoring the complexity and significance of KIF1B in cellular transport mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIF1B Antibody (E-12) References:
- A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. | Gong, TW., et al. 1999. Gene. 239: 117-27. PMID: 10571041
- Molecular motors and their role in membrane traffic. | Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
- Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. | Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
- Kinesin-II, the heteromeric kinesin. | Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
- Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. | Zhao, C., et al. 2001. Cell. 105: 587-97. PMID: 11389829
- Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. | Yang, HW., et al. 2001. Oncogene. 20: 5075-83. PMID: 11526494
- KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. | Nangaku, M., et al. 1994. Cell. 79: 1209-20. PMID: 7528108
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIF1B Antibody (E-12) | sc-376246 | 200 µg/ml | $322.00 | |||
KIF1B Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-529842 | 200 µg Ab; 10 µg BP | $361.00 | |||
KIF1B Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-522890 | 200 µg Ab, 40 µg BP | $361.00 | |||
KIF1B Antibody (E-12): m-IgG1 BP-HRP Bundle | sc-543717 | 200 µg Ab; 20 µg BP | $361.00 | |||
KIF1B Antibody (E-12) AC | sc-376246 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KIF1B Antibody (E-12) HRP | sc-376246 HRP | 200 µg/ml | $322.00 | |||
KIF1B Antibody (E-12) FITC | sc-376246 FITC | 200 µg/ml | $336.00 | |||
KIF1B Antibody (E-12) PE | sc-376246 PE | 200 µg/ml | $349.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 488 | sc-376246 AF488 | 200 µg/ml | $364.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 546 | sc-376246 AF546 | 200 µg/ml | $364.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 594 | sc-376246 AF594 | 200 µg/ml | $364.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 647 | sc-376246 AF647 | 200 µg/ml | $364.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 680 | sc-376246 AF680 | 200 µg/ml | $364.00 | |||
KIF1B Antibody (E-12) Alexa Fluor® 790 | sc-376246 AF790 | 200 µg/ml | $364.00 |