KIF14 Antibody (E-3): sc-365553

KIF14 Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIF14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIF14 (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Kinesin family member 14 (KIF14) plays a crucial role in cellular processes, particularly in regulating cell division and axonal transport, which are vital for maintaining cellular integrity and function. KIF14 is primarily located in the cytoplasm, where KIF14 interacts with microtubules to facilitate transport of organelles and protein complexes, ensuring essential molecules, such as mRNA, are delivered to appropriate destinations within the cell. KIF14 is particularly important in neuronal cells, where KIF14 contributes to development and maintenance of neuronal networks. Notably, KIF14 has been identified as an overexpressed potential oncogene in the 1q region of genomic gain in breast cancer cell lines, associated with poor prognosis. The amplification of chromosome 1q, reflecting oncogene amplification, underscores KIF14′s significance as a potential therapeutic target and biomarker for oncogenesis, making KIF14 a critical focus for cancer research and treatment strategies.

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KIF14 Antibody (E-3) References:

1. All kinesin superfamily protein, KIF, genes in mouse and human.  |  Miki, H., et al. 2001. Proc Natl Acad Sci U S A. 98: 7004-11. PMID: 11416179
2. Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.  |  Mburu, P., et al. 2003. Nat Genet. 34: 421-8. PMID: 12833159
3. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.  |  Zhu, C., et al. 2005. Mol Biol Cell. 16: 3187-99. PMID: 15843429
4. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.  |  Corson, TW., et al. 2005. Oncogene. 24: 4741-53. PMID: 15897902
5. KIF14 and citron kinase act together to promote efficient cytokinesis.  |  Gruneberg, U., et al. 2006. J Cell Biol. 172: 363-72. PMID: 16431929
6. KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.  |  Corson, TW. and Gallie, BL. 2006. Int J Cancer. 119: 1088-94. PMID: 16570270
7. RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.  |  Carleton, M., et al. 2006. Mol Cell Biol. 26: 3853-63. PMID: 16648480
8. KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.  |  Yang, Z., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 181-192. PMID: 30404039
9. KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation.  |  Liu, L., et al. 2023. Arch Biochem Biophys. 737: 109551. PMID: 36822388
10. KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma.  |  Jiang, W., et al. 2023. Oncogene. 42: 1392-1404. PMID: 36922675
11. BUB1/KIF14 complex promotes anaplastic thyroid carcinoma progression by inducing chromosome instability.  |  Jin, T., et al. 2024. J Cell Mol Med. 28: e18182. PMID: 38498903
12. The movement of kinesin along microtubules.  |  Howard, J. 1996. Annu Rev Physiol. 58: 703-29. PMID: 8815816

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF14 Antibody (E-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF14 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF14 Antibody (E-3) Specifications

Alternate Product Name: KIF14

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1141-1380

Epitope Target: KIF14

Epitope Species: human

Product Reactivity/Detection: KIF14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for KIF14 Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin