KCNQ4 Antibody (F-10): sc-271320

KCNQ4 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects KCNQ4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KCNQ4 antibody (F-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNQ4 plays a crucial role in the auditory system, specifically in the function of sensory outer hair cells, which are essential for normal hearing. Mutations in KCNQ4 can disrupt potassium ion flow necessary for proper functioning of these hair cells, leading to auditory deficits and deafness. Understanding KCNQ4 structure and function is vital, as KCNQ4 is part of the KCNQ family of potassium channels that regulate electrical signaling in various tissues, including the brain and inner ear. KCNQ4 is characterized by six transmembrane domains, which are critical for forming potassium ion channels. Using KCNQ4 (F-10) antibody in research can help explore implications of KCNQ4 mutations in auditory pathologies and contribute to understanding genetic factors in hearing loss.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KCNQ4 Antibody (F-10) References:

1. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.  |  Kubisch, C., et al. 1999. Cell. 96: 437-46. PMID: 10025409
2. KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.  |  Nie, L. 2008. Curr Opin Otolaryngol Head Neck Surg. 16: 441-4. PMID: 18797286
3. Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4.  |  Zheng, H., et al. 2022. Genome Res. 32: 1573-1584. PMID: 35760561
4. The Pathological Mechanisms of Hearing Loss Caused by KCNQ1 and KCNQ4 Variants.  |  Homma, K. 2022. Biomedicines. 10: PMID: 36140355
5. LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer.  |  Zhang, Y., et al. 2023. Mol Cancer. 22: 41. PMID: 36859185
6. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns.  |  Singh, NA., et al. 1998. Nat Genet. 18: 25-9. PMID: 9425895
7. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family.  |  Charlier, C., et al. 1998. Nat Genet. 18: 53-5. PMID: 9425900
8. A potassium channel mutation in neonatal human epilepsy.  |  Biervert, C., et al. 1998. Science. 279: 403-6. PMID: 9430594
9. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.  |  Yang, WP., et al. 1998. J Biol Chem. 273: 19419-23. PMID: 9677360
10. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.  |  Wang, HS., et al. 1998. Science. 282: 1890-3. PMID: 9836639
11. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.  |  Schroeder, BC., et al. 1998. Nature. 396: 687-90. PMID: 9872318

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KCNQ4 Antibody (F-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KCNQ4 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KCNQ4 Antibody (F-10) Specifications

Alternate Product Name: KCNQ4

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 349-478

Epitope Target: KCNQ4

Epitope Species: human

Product Reactivity/Detection: KCNQ4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KCNQ4 Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin