KCNH1 Antibody (C-11): sc-398585
- KCNH1 Antibody (C-11) is a mouse monoclonal IgG1 κ KCNH1 antibody provided at 200 µg/ml
- raised against amino acids 751-875 mapping near the C-terminus of KCNH1 of human origin
- KCNH1 Antibody (C-11) is recommended for detection of KCNH1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KCNH1 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KCNH1 Antibody (C-11) for WB applications. These reagents are now offered in bundles with KCNH1 Antibody (C-11) (see ordering information below).
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KCNH1 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects KCNH1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNH1 Antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNH1 protein, also known as potassium voltage-gated channel, subfamily H (eag-related), member 1, plays a critical role in regulating cellular excitability, particularly in the nervous system, by controlling the flow of potassium ions across the cell membrane. This regulation is vital for maintaining the membrane potential and influencing the frequency and structure of action potentials, which are essential for proper neuronal signaling. KCNH1 is a multi-pass membrane protein consisting of 989 amino acids and is encoded by a gene located on human chromosome 1. KCNH1 forms two alternatively spliced isoforms and serves as a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. Notably, KCNH1 forms heteromultimers with KCNH5 and interacts with ALG10, highlighting KCNH1′s importance in cellular signaling pathways and potential implications in various neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KCNH1 Antibody (C-11) References:
- Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines. | Ding, XW., et al. 2007. World J Gastroenterol. 13: 1257-61. PMID: 17451210
- Expression and prognostic roles of Eag1 in resected esophageal squamous cell carcinomas. | Ding, XW., et al. 2008. Dig Dis Sci. 53: 2039-44. PMID: 18080766
- Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells. | Spitzner, M., et al. 2008. J Biol Chem. 283: 7421-8. PMID: 18222922
- Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. | Martin, S., et al. 2008. Neuroscience. 155: 833-44. PMID: 18650019
- Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. | Downie, BR., et al. 2008. J Biol Chem. 283: 36234-40. PMID: 18927085
- A family of potassium channel genes related to eag in Drosophila and mammals. | Warmke, JW. and Ganetzky, B. 1994. Proc Natl Acad Sci U S A. 91: 3438-42. PMID: 8159766
- Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. | Occhiodoro, T., et al. 1998. FEBS Lett. 434: 177-82. PMID: 9738473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KCNH1 Antibody (C-11) | sc-398585 | 200 µg/ml | $322.00 | |||
KCNH1 Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-530855 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNH1 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-524404 | 200 µg Ab, 40 µg BP | $361.00 | |||
KCNH1 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-544281 | 200 µg Ab; 20 µg BP | $361.00 | |||
KCNH1 Antibody (C-11) AC | sc-398585 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KCNH1 Antibody (C-11) HRP | sc-398585 HRP | 200 µg/ml | $322.00 | |||
KCNH1 Antibody (C-11) FITC | sc-398585 FITC | 200 µg/ml | $336.00 | |||
KCNH1 Antibody (C-11) PE | sc-398585 PE | 200 µg/ml | $349.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 488 | sc-398585 AF488 | 200 µg/ml | $364.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 546 | sc-398585 AF546 | 200 µg/ml | $364.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 594 | sc-398585 AF594 | 200 µg/ml | $364.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 647 | sc-398585 AF647 | 200 µg/ml | $364.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 680 | sc-398585 AF680 | 200 µg/ml | $364.00 | |||
KCNH1 Antibody (C-11) Alexa Fluor® 790 | sc-398585 AF790 | 200 µg/ml | $364.00 |