KAT III Antibody (A-7): sc-365219
- KAT III Antibody (A-7) is a mouse monoclonal IgG1 κ KAT III antibody provided at 200 µg/ml
- raised against amino acids 1-65 mapping at the N-terminus of KAT III of mouse origin
- KAT III Antibody (A-7) is recommended for detection of KAT III of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KAT III Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KAT III Antibody (A-7) for WB applications. These reagents are now offered in bundles with KAT III Antibody (A-7) (see ordering information below).
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KAT III Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects KAT III protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KAT III (A-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Kynurenine aminotransferases, which include KAT I, KAT II, and KAT III, are part of the class-I pyridoxal-phosphate-dependent aminotransferase family. KAT III is predominantly expressed in the liver, heart, kidney, and neuroendocrine tissues, where KAT III plays a crucial role in the transamination of kynurenine to produce kynurenic acid, a metabolite of tryptophan that exhibits neuroprotective and anticonvulsant properties. The significance of kynurenic acid lies in its involvement in synaptic transmission and potential implications in various neurological disorders, such as schizophrenia and Huntington′s disease, highlighting KAT III′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KAT III Antibody (A-7) References:
- Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti(1). | Fang, J., et al. 2002. Insect Biochem Mol Biol. 32: 943-50. PMID: 12110301
- Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs. | Mosca, M., et al. 2003. Biochim Biophys Acta. 1628: 1-10. PMID: 12850267
- Kynurenine metabolism in multiple sclerosis. | Hartai, Z., et al. 2005. Acta Neurol Scand. 112: 93-6. PMID: 16008534
- Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. | Yu, P., et al. 2006. Gene. 365: 111-8. PMID: 16376499
- Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain. | Malherbe, P., et al. 1995. FEBS Lett. 367: 141-4. PMID: 7796908
- Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase. | Alberati-Giani, D., et al. 1995. J Neurochem. 64: 1448-55. PMID: 7891071
- Kynurenic acid and kynurenine aminotransferase in heart. | Baran, H., et al. 1997. Pediatr Res. 41: 404-10. PMID: 9078543
- Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney. | Buchli, R., et al. 1995. J Biol Chem. 270: 29330-5. PMID: 7493966
- Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease. | Sapko, MT., et al. 2006. Exp Neurol. 197: 31-40. PMID: 16099455
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KAT III Antibody (A-7) | sc-365219 | 200 µg/ml | $322.00 | |||
KAT III Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-529328 | 200 µg Ab; 10 µg BP | $361.00 | |||
KAT III Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-522165 | 200 µg Ab, 40 µg BP | $361.00 | |||
KAT III Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-543461 | 200 µg Ab; 20 µg BP | $361.00 | |||
KAT III Antibody (A-7) AC | sc-365219 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KAT III Antibody (A-7) HRP | sc-365219 HRP | 200 µg/ml | $322.00 | |||
KAT III Antibody (A-7) FITC | sc-365219 FITC | 200 µg/ml | $336.00 | |||
KAT III Antibody (A-7) PE | sc-365219 PE | 200 µg/ml | $349.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 488 | sc-365219 AF488 | 200 µg/ml | $364.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 546 | sc-365219 AF546 | 200 µg/ml | $364.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 594 | sc-365219 AF594 | 200 µg/ml | $364.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 647 | sc-365219 AF647 | 200 µg/ml | $364.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 680 | sc-365219 AF680 | 200 µg/ml | $364.00 | |||
KAT III Antibody (A-7) Alexa Fluor® 790 | sc-365219 AF790 | 200 µg/ml | $364.00 |