KAT I Antibody (H-11): sc-374590

KAT I Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects KAT I in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KAT I is a crucial cytoplasmic enzyme belonging to the class-I pyridoxal-phosphate-dependent aminotransferase family, playing a significant role in glutamine catabolism. KAT I (H-11) antibody recognizes an enzyme that catalyzes the transamination of L-kynurenine to produce kynurenic acid, a metabolite derived from tryptophan that exhibits neuroprotective and anticonvulsant properties. The importance of kynurenic acid lies in its involvement in synaptic transmission and its potential implications in various neurological disorders, including schizophrenia and Huntington′s disease. Additionally, KAT I is implicated in the metabolism of cysteine conjugates from certain halogenated alkenes and alkanes, leading to the formation of reactive metabolites. KAT I has three isoforms, with isoform 1 representing the full-length protein, while isoform 2 is missing amino acids 68-117 and isoform 3 lacks amino acids 251-422. Based on sequence similarity, KAT I is believed to function as a homodimer, further emphasizing its structural significance in enzymatic activity and metabolic processes. Anti-KAT I antibody (H-11) is an essential tool for researchers studying the intricate roles of KAT I in health and disease.

The preferred KAT I antibody is KAT I Antibody (C-7): sc-374531.