Anti-karyopherin α5 Antibody (H-4) is a mouse monoclonal IgG1 (kappa light chain) karyopherin α5 antibody provided at 200 µg/ml
raised against amino acids 51-100 mapping near the N-terminus of karyopherin α5 of human origin
karyopherin alpha 5 Antibody (H-4) is recommended for detection of karyopherin α5 of human origin by WB, IP, IF and ELISA
Anti-karyopherin alpha 5 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of karyopherin α5 (H-4): sc-515870.
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karyopherin α5 Antibody (H-4) is a high quality monoclonal karyopherin alpha 5 antibody (also designated karyopherin α5 antibody) suitable for the detection of the karyopherin alpha 5 protein of human origin. karyopherin α5 Antibody (H-4) is available as both the non-conjugated anti-karyopherin alpha 5 antibody form, as well as multiple conjugated forms of anti-karyopherin alpha 5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Cytoplasmic proteins that contain nuclear localization signals (NLSs) must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Karyopherin α5, also known as SRP6 or IPOA6, is a 536 amino acid protein that contains ten ARM repeats and one IBB domain and belongs to the importin α family. Expressed specifically in the testis, karyopherin α5 binds to proteins containing an NLS motif and directs them to the NPC for transport into the nucleus. Specifically, karyopherin α5 is thought to bind nuclear-targeted proteins through its IBB domain which acts as an intrasteric autoregulatory sequence that interacts with the target NLS domain. Due to its ability to direct proteins to the NPC for import, karyopherin α5 may be involved in the nuclear localization of HIV-1 and may, thus, be involved in the pathogenesis of the disease.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
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