κB-Ras2 Antibody (C-11): sc-374312

κB-Ras2 Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects κB-Ras2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). κB-Ras2 is a member of the IκB-interacting Ras-like protein family, which plays a crucial role in the regulation of cellular pathways, particularly those involving the NFκB signaling cascade. κB-Ras2 is primarily located in the cytoplasm, where κB-Ras2 interacts with IκB proteins, specifically IκB-α and IκB-β, to modulate their degradation rates. The ability of κB-Ras2 to stabilize IκB-β is particularly significant, as κB-Ras2 contributes to the controlled activation of NFκB, a transcription factor that regulates genes involved in immune response, cell proliferation, and survival. By preventing the degradation of IκB-β, κB-Ras2 helps maintain the balance of NFκB activity, which is essential for normal cellular function and response to stress. The unique structural features of κB-Ras2, including amino acid composition that resembles oncogenic Ras proteins, further underscore κB-Ras2′s importance in cellular signaling and potential implications in cancer biology. With versatile applications and critical role in cellular regulation, anti-κB-Ras2 antibody (C-11) serves as an invaluable tool for researchers studying the complexities of Ras signaling and NFκB pathways.

The preferred κB-Ras2 antibody is κB-Ras2 Antibody (F-12): sc-374311.