KRAS Antibody (3B10-2F2): sc-517599

K-Ras Antibody (3B10-2F2) is a mouse monoclonal IgG1 kappa light chain antibody. Anti-K-Ras antibody (3B10-2F2) is raised against full-length recombinant human K-Ras protein, and demonstrates reactivity with human K-Ras in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). K-Ras protein is a crucial member of the Ras family of small GTPases, acting as a molecular switch in signal transduction pathways that regulate cell proliferation, differentiation, and survival. K-Ras functions by cycling between an active GTP-bound state and an inactive GDP-bound state, a process tightly controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Proper functioning of K-Ras is essential for normal cellular responses to growth signals, however, mutations in the KRAS gene, particularly at codons 12, 13, and 61, can lead to constitutive activation of K-Ras protein. This aberrant activation results in continuous cell division and survival signaling, contributing significantly to the development and progression of various cancers, including pancreatic, colorectal, and lung cancers. Understanding the role of K-Ras in oncogenesis is vital for cancer research and the development of targeted therapies. K-Ras monoclonal antibody (3B10-2F2) serves as an invaluable tool for researchers aiming to detect and study K-Ras expression and function in both normal and diseased states, thereby advancing insights into cancer mechanisms and aiding in the creation of effective therapeutic strategies.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KRAS Antibody (3B10-2F2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KRAS Antibody (3B10-2F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KRAS Antibody (3B10-2F2) Specifications

Alternate Product Name: KRAS

Product Clone Name: 3B10-2F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-188

Epitope Target: K-Ras

Epitope Species: human

Product Reactivity/Detection: K-Ras

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KRAS Antibody (3B10-2F2): N/A

The preferred KRAS antibody is KRAS Antibody (F234): sc-30.