JP-45 Antibody (H-11): sc-377297
- JP-45 Antibody (H-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 191-223 within an internal region of JP-45 of mouse origin
- recommended for detection of JP-45 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JP-45 Antibody (H-11) for WB applications. These reagents are now offered in bundles with JP-45 Antibody (H-11) (see ordering information below).
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SEE ALSO...
JP-45 Antibody (H-11) is a mouse monoclonal IgG2b antibody that detects JP-45 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JP-45, also known as junctional sarcoplasmic reticulum protein 1 (JSRP1), is a 331 amino acid protein located in the sarcoplasmic and endoplasmic reticulum membranes, playing a crucial role in muscle physiology. JSRP1 (H-11) antibody helps study the regulation of the L-type calcium channel, specifically the L-type Ca++ channel α1S, through interactions with L-type Ca++ channel β1B and calsequestrin. These interactions are vital for proper excitation-contraction coupling in muscle cells, essential for muscle contraction and overall muscle health. The gene encoding JP-45 is located on human chromosome 19p13.3, and while silencing this gene doesn′t affect postnatal development, JP-45 deficiency can lead to decreased muscle strength, highlighting its importance in skeletal muscle development and maintenance. Anti-JP-45 antibody (H-11) serves as an invaluable tool for researchers studying muscle biology and related disorders, providing insights into molecular mechanisms underlying muscle function and integrity.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JP-45 Antibody (H-11) | sc-377297 | 200 µg/ml | $316.00 | |||
JP-45 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-538033 | 200 µg Ab; 10 µg BP | $354.00 | |||
JP-45 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-535555 | 200 µg Ab; 40 µg BP | $354.00 | |||
JP-45 (H-11) Neutralizing Peptide | sc-377297 P | 100 µg/0.5 ml | $68.00 |