JIP-1 Antibody (2J8): sc-53552

JIP-1 Antibody (2J8) is a mouse monoclonal IgG1 antibody that detects JIP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JIP-1, or JNK interacting protein-1, plays a crucial role in regulating the c-Jun NH2-terminal kinase (JNK) signaling pathway, which is vital for cellular responses to stress, including ultraviolet light exposure. By binding to JNK, JIP-1 acts as a cytoplasmic inhibitor, sequestering JNK and preventing translocation to the nucleus where JNK would otherwise activate gene expression related to stress responses. This interaction helps maintain cellular homeostasis and prevents excessive activation of stress-related genes, which could lead to pathological conditions. The presence of multiple splice variants of JIP-1, such as JIP-1b and JIP-1c, further highlights the complexity of regulatory functions in different tissues, especially in the brain. Anti-JIP-1 antibody (2J8) is an essential tool for researchers studying the intricate mechanisms of JNK signaling and its implications in various diseases.

The preferred JIP-1 antibody is JIP-1 Antibody (B-7): sc-25267.