JAKMIP2 Antibody (G-2): sc-393578

JAKMIP2 Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects JAKMIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). JAKMIP2 (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JAKMIP2, also known as janus kinase and microtubule-interacting protein 2, NECC1, CTCL tumor antigen HD-CL-04, JAMIP2, or KIAA0555, consists of 810 amino acids and is a member of the JAKMIP family. JAKMIP2 is primarily localized to the Golgi apparatus, which is crucial for protein sorting and trafficking within the cell. The Golgi apparatus is essential for post-translational modification of proteins, and JAKMIP2′s localization suggests a significant role in processing and transport of proteins involved in cellular signaling pathways. JAKMIP2 is highly expressed in the brain, with moderate expression levels found in the thymus, spleen, and lung, indicating potential involvement in neuroendocrine functions and immune responses. The gene encoding JAKMIP2 is located on human chromosome 5q32 and mouse chromosome 18 B3, with the human chromosome containing 181 million base pairs, accounting for nearly 6% of the human genome. Notably, deletions in chromosome 5 are associated with various syndromes and malignancies, highlighting JAKMIP2′s importance in both normal physiology and disease states.

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JAKMIP2 Antibody (G-2) References:

1. Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case.  |  Finch, R., et al. 2005. Dis Colon Rectum. 48: 2148-52. PMID: 16228830
2. Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas.  |  Laé, M., et al. 2007. J Pathol. 212: 143-51. PMID: 17471488
3. Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.  |  Anindya, R., et al. 2007. Mol Cell. 28: 386-97. PMID: 17996703
4. Haematological & molecular profile of acute myelogenous leukaemia in India.  |  Sazawal, S., et al. 2009. Indian J Med Res. 129: 256-61. PMID: 19491417
5. Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities.  |  Ravandi, F., et al. 2009. Cancer. 115: 5746-51. PMID: 19795507
6. Characterization of a de novo complex chromosomal rearrangement in a patient with cri-du-chat and trisomy 5p syndromes.  |  Vera-Carbonell, A., et al. 2009. Am J Med Genet A. 149A: 2513-21. PMID: 19842199
7. The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon.  |  Edwards, SJ., et al. 1997. Am J Hum Genet. 60: 515-24. PMID: 9042910
8. Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome.  |  Crawford, MJ., et al. 1997. Mamm Genome. 8: 841-5. PMID: 9337397
9. Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids.  |  McDaniel, LD., et al. 1997. Hum Mutat. 10: 317-21. PMID: 9338586

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-JAKMIP2 Antibody (G-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-JAKMIP2 Antibody (G-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

JAKMIP2 Antibody (G-2) Specifications

Alternate Product Name: JAKMIP2

Product Clone Name: G-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 377-416

Epitope Target: JAKMIP2

Epitope Species: human

Product Reactivity/Detection: JAKMIP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for JAKMIP2 Antibody (G-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin