IVD Antibody (B-9): sc-271205
- IVD Antibody (B-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 143-186 within an internal region of IVD of human origin
- recommended for detection of IVD of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and bovine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IVD Antibody (B-9) for WB and IHC(P) applications. These reagents are now offered in bundles with IVD Antibody (B-9) (see ordering information below).
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IVD Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IVD antibody (B-9) targets a 423 amino acid protein encoded by the human gene IVD, which is a crucial component of the mitochondrial matrix and belongs to the acyl-CoA dehydrogenase family. IVD functions as a homotetrameric flavoenzyme, playing a vital role in the metabolism of branched-chain amino acids by catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. This enzymatic activity contributes to energy production and maintains metabolic homeostasis. Defects in the IVD gene can lead to ineffective isoforms, resulting in isovaleric acidemia, a metabolic disorder with severe health implications. Two recognized forms of this condition exist: the acute neonatal form, which can lead to rapid metabolic acidosis and death shortly after birth, and a chronic form presenting with intermittent severe ketoacidosis. Understanding IVD function is essential for developing therapeutic strategies for managing these metabolic disorders, making IVD (B-9) monoclonal antibody a valuable research tool.
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IVD Antibody (B-9) References:
- Harnessing the Potential of Mesenchymal Stem Cells for IVD Regeneration. | Clarke, LE., et al. 2015. Curr Stem Cell Res Ther. 10: 296-306. PMID: 25440320
- IVD Development: Nucleus pulposus development and sclerotome specification. | Alkhatib, B., et al. 2018. Curr Mol Biol Rep. 4: 132-141. PMID: 30505649
- Differences in IVD characteristics between low back pain patients and controls associated with HIZ as revealed with quantitative MRI. | Waldenberg, C., et al. 2019. PLoS One. 14: e0220952. PMID: 31437172
- Optimization of a rat lumbar IVD degeneration model for low back pain. | Glaeser, JD., et al. 2020. JOR Spine. 3: e1092. PMID: 32613167
- Therapeutic Strategies for IVD Regeneration through Hyaluronan/SDF-1-Based Hydrogel and Intravenous Administration of MSCs. | Cunha, C., et al. 2021. Int J Mol Sci. 22: PMID: 34502517
- Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration. | Chen, J., et al. 2022. Bioact Mater. 9: 29-43. PMID: 34820553
- BZW2, CDT1 and IVD Act As Biomarkers for Predicting Hepatocellular Carcinoma. | Jiang, Z., et al. 2023. Curr Cancer Drug Targets. 23: 211-221. PMID: 36056860
- Contribution of coronal vertebral and IVD wedging to Cobb angle changes in adolescent idiopathic scoliosis during growth. | Cheung, WK. and Cheung, JPY. 2022. BMC Musculoskelet Disord. 23: 904. PMID: 36217198
- Future of low back pain: unravelling IVD components and MSCs' potential. | Leão Monteiro, R. 2024. Cell Regen. 13: 1. PMID: 38227139
- Modelling of Intervertebral Disc (IVD) with Structured Mesh and Crosswise Collagen Fibers. | Mohammadi, M., et al. 2023. Annu Int Conf IEEE Eng Med Biol Soc. 2023: 1-4. PMID: 38557306
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IVD Antibody (B-9) | sc-271205 | 200 µg/ml | $322.00 | |||
IVD Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-537589 | 200 µg Ab; 10 µg BP | $361.00 | |||
IVD Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-534896 | 200 µg Ab; 40 µg BP | $361.00 | |||
IVD Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-545247 | 200 µg Ab; 20 µg BP | $361.00 | |||
IVD (B-9) Neutralizing Peptide | sc-271205 P | 100 µg/0.5 ml | $69.00 |