ITM2B Antibody (E-11): sc-373874
- ITM2B Antibody (E-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-54 mapping at the N-terminus of ITM2B of human origin
- recommended for detection of ITM2B of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ITM2B Antibody (E-11) for WB applications. These reagents are now offered in bundles with ITM2B Antibody (E-11) (see ordering information below).
QUICK LINKS
ITM2B Antibody (E-11) is a mouse monoclonal IgG2b light chain antibody that detects ITM2B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ITM2B is a 266 amino acid protein that plays a crucial role in cellular signaling and membrane dynamics, particularly in the brain and other tissues. Anti-ITM2B antibody (E-11) recognizes a structure that includes a potential N-glycosylation site and a single transmembrane-spanning domain, which are essential for mediating interactions with other proteins and facilitating cellular communication. Mutations in the ITM2B gene are linked to familial British dementia and familial Danish dementia, both autosomal dominant disorders that manifest with severe neurological symptoms, including dementia and ataxia. ITM2B (E-11) antibody′s ability to effectively detect across various species makes this monoclonal a valuable tool for researchers studying the underlying mechanisms of these neurodegenerative diseases and exploring potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ITM2B Antibody (E-11) References:
- The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. | Baron, BW., et al. 2015. Biochim Biophys Acta. 1852: 742-8. PMID: 25557390
- The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms. | Yao, W., et al. 2019. Sci Rep. 9: 4862. PMID: 30890756
- Generation of human induced pluripotent stem cell lines from a patient with ITM2B-related retinal dystrophy and a non mutated brother. | Wohlschlegel, J., et al. 2019. Stem Cell Res. 41: 101625. PMID: 31731182
- DEEP PHENOTYPING AND FURTHER INSIGHTS INTO ITM2B-RELATED RETINAL DYSTROPHY. | Nassisi, M., et al. 2021. Retina. 41: 872-881. PMID: 32826790
- G-MDSCs-Derived Exosomal miRNA-143-3p Promotes Proliferation via Targeting of ITM2B in Lung Cancer. | Zhou, JH., et al. 2020. Onco Targets Ther. 13: 9701-9719. PMID: 33061450
- Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission. | Yin, T., et al. 2021. J Biol Chem. 296: 100054. PMID: 33172889
- First identification of ITM2B interactome in the human retina. | Wohlschlegel, J., et al. 2021. Sci Rep. 11: 17210. PMID: 34446781
- Generation of gene corrected human isogenic iPSC lines (IDVi003-A_CR13, IDVi003-A_CR21, IDVi003-A_CR24) from an inherited retinal dystrophy patient-derived IPSC line ITM2B-5286-3 (IDVi003-A) carrying the ITM2B c.782A > C variant using CRISPR/Cas9. | Ben Yacoub, T., et al. 2023. Stem Cell Res. 71: 103166. PMID: 37473460
- MicroRNA-196a-5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma. | Xian, D., et al. 2024. Pathol Int. 74: 129-138. PMID: 38289121
- Exosomal miR-196a-5p contributes to esophageal squamous cell carcinoma malignant progression by inhibiting ITM2B. | Huang, M., et al. 2024. Pathol Int. 74: 464-474. PMID: 38940569
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITM2B Antibody (E-11) | sc-373874 | 200 µg/ml | $322.00 | |||
ITM2B Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-535321 | 200 µg Ab; 40 µg BP | $361.00 | |||
ITM2B Antibody (E-11): m-IgG2b BP-HRP Bundle | sc-549393 | 200 µg Ab; 10 µg BP | $361.00 |