ITI-H1 Antibody (F-5): sc-514541
- ITI-H1 Antibody (F-5) is a mouse monoclonal IgG1 κ ITI-H1 antibody provided at 200 µg/ml
- raised against amino acids 607-672 mapping within an internal region of ITI-H1 of human origin
- ITI-H1 Antibody (F-5) is recommended for detection of precursor and mature chain of ITI-H1 of human origin by WB, IP, IF and ELISA
- Anti-ITI-H1 Antibody (F-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of ITI-H1 (F-5): sc-514541.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ITI-H1 Antibody (F-5) for WB applications. This reagent is now offered in a bundle with ITI-H1 Antibody (F-5) (see ordering information below).
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ITI-H1 Antibody (F-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects ITI-H1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ITI-H1 (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The inter-α-trypsin inhibitor (ITI) family, to which ITI-H1 belongs, consists of structurally related plasma serine protease inhibitors synthesized in the liver, comprising different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2, and ITI-H3) and one light chain (Bikunin). ITI-H1 plays a crucial role in regulating proteolytic activity in the extracellular matrix, which is vital for maintaining tissue homeostasis and modulating inflammatory responses. Notably, ITI-H1 interacts with hyaluronic acid, contributing to the stabilization of the pericellular matrix, which is essential for cell signaling and tissue repair processes. Additionally, while ITI-H1, along with ITI-H3 and Bikunin, exhibits anti-tumoral and antimetastatic properties, ITI-H1 is also implicated in the malignant transformation of lung tissue and is associated with calcium oxalate stone formation in the kidney and urine. The diverse functions and interactions of ITI-H1 underscore its importance in both physiological and pathological contexts, making anti-ITI-H1 antibody (F-5) a valuable tool for researchers studying these complex biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ITI-H1 Antibody (F-5) References:
- Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue. | Bourguignon, J., et al. 1999. J Histochem Cytochem. 47: 1625-32. PMID: 10567446
- Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. | Zhuo, L., et al. 2001. J Biol Chem. 276: 7693-6. PMID: 11145954
- Expression of inter-alpha inhibitor related proteins in kidneys and urine of hyperoxaluric rats. | Moriyama, MT., et al. 2001. J Urol. 165: 1687-92. PMID: 11342956
- Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains. | Paris, S., et al. 2002. Int J Cancer. 97: 615-20. PMID: 11807786
- The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. | Soury, E., et al. 1998. Biochem Biophys Res Commun. 243: 522-30. PMID: 9480842
- Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues. | Mizushima, S., et al. 1998. Biol Pharm Bull. 21: 167-9. PMID: 9514613
- Inter-alpha-trypsin inhibitor proteoglycan family--a group of proteins binding and stabilizing the extracellular matrix. | Bost, F., et al. 1998. Eur J Biochem. 252: 339-46. PMID: 9546647
- Inter-alpha-inhibitor in calcium stones. | Dawson, CJ., et al. 1998. Clin Sci (Lond). 95: 187-93. PMID: 9680501
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITI-H1 Antibody (F-5) | sc-514541 | 200 µg/ml | $316.00 | |||
ITI-H1 Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-526377 | 200 µg Ab; 10 µg BP | $354.00 | |||
ITI-H1 Antibody (F-5) AC | sc-514541 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ITI-H1 Antibody (F-5) HRP | sc-514541 HRP | 200 µg/ml | $316.00 | |||
ITI-H1 Antibody (F-5) FITC | sc-514541 FITC | 200 µg/ml | $330.00 | |||
ITI-H1 Antibody (F-5) PE | sc-514541 PE | 200 µg/ml | $343.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 488 | sc-514541 AF488 | 200 µg/ml | $357.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 546 | sc-514541 AF546 | 200 µg/ml | $357.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 594 | sc-514541 AF594 | 200 µg/ml | $357.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 647 | sc-514541 AF647 | 200 µg/ml | $357.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 680 | sc-514541 AF680 | 200 µg/ml | $357.00 | |||
ITI-H1 Antibody (F-5) Alexa Fluor® 790 | sc-514541 AF790 | 200 µg/ml | $357.00 |