ITF Antibody (15C6): sc-81467
- ITF Antibody (15C6) is a mouse monoclonal IgG1, cited in 6 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-12 corresponding to the N-terminus of ITF of human origin
- recommended for detection of ITF of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ITF Antibody (15C6). This work is in progress.
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ITF Antibody (15C6) is a mouse monoclonal IgG1 antibody that detects intestinal trefoil factor (ITF) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ITF plays a crucial role in maintaining the integrity of the intestinal epithelium, particularly during mucosal healing processes, which is vital for recovery from injury and inflammation in the gastrointestinal tract. ITF is predominantly expressed in the epithelial mucosal layer of the small intestine and colon, as well as in the brain and pituitary gland, highlighting its importance beyond just gastrointestinal health. The unique structure of ITF, characterized by three intrachain disulfide bonds that form the trefoil motif, is essential for stability and function, allowing resistance to proteolytic degradation and effectively promoting epithelial cell migration and proliferation in response to injury. ITF is upregulated in areas of epithelial damage and in various neoplastic conditions, making ITF a significant marker for assessing mucosal health and disease progression. The genes encoding ITF, along with other trefoil peptides, are located on human chromosome 21q22.3, indicating a potential genetic basis for their coordinated expression and function in mucosal defense mechanisms.
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ITF Antibody (15C6) References:
- Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. | Taupin, DR., et al. 2000. Proc Natl Acad Sci U S A. 97: 799-804. PMID: 10639160
- Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds. | Paulsen, FP., et al. 2008. J Biol Chem. 283: 13418-27. PMID: 18326859
- Recombinant adenovirus-mediated intestinal trefoil factor gene therapy for burn-induced intestinal mucosal injury. | Sun, Y., et al. 2013. PLoS One. 8: e62429. PMID: 23638081
- Kinetic characterization of an intestinal trefoil factor receptor. | Yong, Z., et al. 2013. PLoS One. 8: e74669. PMID: 24086361
- Intestinal trefoil factor activates the PI3K/Akt signaling pathway to protect gastric mucosal epithelium from damage. | Sun, Z., et al. 2014. Int J Oncol. 45: 1123-32. PMID: 24990304
- Intestinal Trefoil Factor 3 Alleviates the Intestinal Barrier Function Through Reducing the Expression of TLR4 in Rats with Nonalcoholic Steatohepatitis. | Wang, Y., et al. 2019. Arch Med Res. 50: 2-9. PMID: 31101239
- Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling. | Huang, Y., et al. 2020. World J Gastroenterol. 26: 7619-7632. PMID: 33505140
- Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. | Podolsky, DK., et al. 1993. J Biol Chem. 268: 6694-702. PMID: 8454642
- Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells. | Kanai, M., et al. 1998. Proc Natl Acad Sci U S A. 95: 178-82. PMID: 9419349
- Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas. | Uchino, H., et al. 1997. J Clin Pathol. 50: 932-4. PMID: 9462243
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ITF Antibody (15C6) | sc-81467 | 50 µg/0.5 ml | $322.00 |