ISY1 Antibody (G-6): sc-398437
- ISY1 Antibody (G-6) is a mouse monoclonal IgG1 κ ISY1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-139 mapping at the N-terminus of ISY1 of human origin
- ISY1 Antibody (G-6) is recommended for detection of ISY1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and avian
- Anti-ISY1 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of ISY1 (G-6): sc-398437.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ISY1 Antibody (G-6) for WB applications. These reagents are now offered in bundles with ISY1 Antibody (G-6) (see ordering information below).
QUICK LINKS
ISY1 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ISY1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ISY1 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ISY1, consisting of 331 amino acids, plays a crucial role in the spliceosome C complex, which is essential for the splicing of pre-mRNA—a vital process in the posttranscriptional regulation of gene expression. Proper functioning of ISY1 contributes to the accuracy of mRNA splicing, thereby influencing the production of functional proteins and overall gene expression profile within cells. Additionally, ISY1 exists in three isoforms due to alternative splicing, and is located on chromosome 3, which harbors over 1,100 genes, including those related to chemokine receptors and various cancer-related loci. Anti-ISY1 antibody (G-6) serves as an invaluable tool for researchers studying the dynamics of mRNA processing and its implications in cellular function and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ISY1 Antibody (G-6) References:
- The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae. | Dix, I., et al. 1999. RNA. 5: 360-8. PMID: 10094305
- Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution. | Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
- Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. | Dahan, O. and Kupiec, M. 2002. Nucleic Acids Res. 30: 4361-70. PMID: 12384582
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Plasticity of human chromosome 3 during primate evolution. | Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
- Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2. | Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
- Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution. | Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
- Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'. | Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
- The DNA sequence, annotation and analysis of human chromosome 3. | Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
- Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3. | Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ISY1 Antibody (G-6) | sc-398437 | 200 µg/ml | $316.00 | |||
ISY1 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-530798 | 200 µg Ab; 10 µg BP | $354.00 | |||
ISY1 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-524341 | 200 µg Ab, 40 µg BP | $354.00 | |||
ISY1 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-544258 | 200 µg Ab; 20 µg BP | $354.00 | |||
ISY1 Antibody (G-6) AC | sc-398437 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ISY1 Antibody (G-6) HRP | sc-398437 HRP | 200 µg/ml | $316.00 | |||
ISY1 Antibody (G-6) FITC | sc-398437 FITC | 200 µg/ml | $330.00 | |||
ISY1 Antibody (G-6) PE | sc-398437 PE | 200 µg/ml | $343.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 488 | sc-398437 AF488 | 200 µg/ml | $357.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 546 | sc-398437 AF546 | 200 µg/ml | $357.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 594 | sc-398437 AF594 | 200 µg/ml | $357.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 647 | sc-398437 AF647 | 200 µg/ml | $357.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 680 | sc-398437 AF680 | 200 µg/ml | $357.00 | |||
ISY1 Antibody (G-6) Alexa Fluor® 790 | sc-398437 AF790 | 200 µg/ml | $357.00 |