Islet-1 Antibody (B-1): sc-390793

Islet-1 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Islet-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Islet-1 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Islet-1 protein, also known as ISL LIM Homeobox 1, plays a crucial role in pancreatic islets of Langerhans development and is essential for motor neuron differentiation in the neural tube. Islet-1 influences embryonic development and organogenesis, particularly in heart and pancreas, where Islet-1 helps define cardiac progenitor cell populations and is necessary for normal cardiac development and asymmetry. Islet-1 is involved in patterning developing mouse teeth by activating Bmp4 expression in specific areas, demonstrating importance in both developmental biology and potential implications in regenerative medicine. Islet-1 interaction with other transcription factors and signaling pathways further underscores significance in cellular differentiation and organ development, making Islet-1 (B-1) monoclonal antibody an invaluable tool for researchers studying these critical biological processes.

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Islet-1 Antibody (B-1) References:

1. Role of Islet1 in the patterning of murine dentition.  |  Mitsiadis, TA., et al. 2003. Development. 130: 4451-60. PMID: 12900460
2. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart.  |  Cai, CL., et al. 2003. Dev Cell. 5: 877-89. PMID: 14667410
3. Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish.  |  Yeo, SY., et al. 2004. Mech Dev. 121: 315-24. PMID: 15110042
4. Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding.  |  Pak, W., et al. 2004. Cell. 119: 567-78. PMID: 15537545
5. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.  |  Du, A., et al. 2009. Diabetes. 58: 2059-69. PMID: 19502415
6. Islet-1 expression in thoracic spinal motor neurons in prenatal mouse.  |  Kobayashi, M., et al. 2011. Int J Dev Neurosci. 29: 749-56. PMID: 21651972
7. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.  |  Galloway, JR., et al. 2015. Mol Endocrinol. 29: 1774-86. PMID: 26495868
8. Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression.  |  Shan, Y., et al. 2020. Front Cell Dev Biol. 8: 35. PMID: 32083082
9. The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome.  |  Camberos, V., et al. 2021. Int J Mol Sci. 22: PMID: 33808224
10. The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage.  |  Wang, M. and Drucker, DJ. 1994. Endocrinology. 134: 1416-22. PMID: 7907017
11. Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected].  |  Tanizawa, Y., et al. 1994. Diabetes. 43: 935-41. PMID: 7912209
12. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation.  |  Pfaff, SL., et al. 1996. Cell. 84: 309-20. PMID: 8565076

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Islet-1 Antibody (B-1) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Islet-1 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Islet-1 Antibody (B-1) Specifications

Alternate Product Name: ISL1

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 244-282

Epitope Target: Islet-1

Epitope Species: human

Product Reactivity/Detection: Islet-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Islet-1 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent