Anti-IRF-6 Antibody (F-12) is a mouse monoclonal IgG1 κ IRF-6 antibody, cited in 2 publications, provided at 200 µg/ml
raised against amino acids 91-229 mapping within an internal region of IRF-6 of human origin
Anti-IRF-6 Antibody (F-12) is recommended for detection of IRF-6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and bovine
Anti-IRF-6 Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of IRF-6 (F-12): sc-377043.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IRF-6 Antibody (F-12) is a high quality monoclonal IRF-6 antibody (also designated IRF6 antibody) suitable for the detection of the IRF-6 protein of mouse, rat and human origin. IRF-6 Antibody (F-12) is available as both the non-conjugated anti-IRF-6 antibody form, as well as multiple conjugated forms of anti-IRF-6 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rated 1 out of
No endogenous signal by WesternWas unable to detect endogenous levels of IRF6 in either human or mouse tissues and cell cultures that had worked with other IRF6 antibodies we've previously published.
Date published: 2018-12-13
Rated 5 out of
Wonderful cytoplasmic staining of keratinocytesWonderful cytoplasmic staining of keratinocytes, fibroblasts, Langerhans cells and melanocytes in paraffin-embedded human skin tissue by IHC. -SCBT QC
Date published: 2015-04-23
Rated 5 out of
Great Western blot data obtained in JurkatGreat Western blot data obtained in Jurkat whole cell lysate. -SCBT QC
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