IRF-6 Antibody (F-12): sc-377043

IRF-6 Antibody (F-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects IRF-6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-IRF-6 antibody (F-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IRF-6 plays a crucial role in regulating gene expression during development, particularly in epidermis formation and palate development. Proper IRF-6 function is essential for preventing congenital defects such as cleft lip and palate, highlighting IRF-6′s importance in developmental biology. Mutations in IRF-6 have been linked to these conditions, underscoring IRF-6′s significance in both normal development and disease. Additionally, IRF-6 interacts with other proteins in the interferon regulatory factor family, which collectively regulate immune responses and cellular growth, further emphasizing IRF-6′s role in maintaining cellular homeostasis and responding to environmental signals.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IRF-6 Antibody (F-12) References:

1. Interferon regulatory factors: the next generation.  |  Mamane, Y., et al. 1999. Gene. 237: 1-14. PMID: 10524230
2. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.  |  Kondo, S., et al. 2002. Nat Genet. 32: 285-9. PMID: 12219090
3. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate.  |  Zucchero, TM., et al. 2004. N Engl J Med. 351: 769-80. PMID: 15317890
4. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRF-6 Antibody (F-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IRF-6 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRF-6 Antibody (F-12) Specifications

Alternate Product Name: IRF-6

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 91-229

Epitope Target: IRF-6

Epitope Species: human

Product Reactivity/Detection: IRF-6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IRF-6 Antibody (F-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin