IRF-4 Antibody (E-7): sc-377383

IRF-4 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects interferon regulatory factor-4 (IRF-4) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-4 is a crucial transcription factor that plays a significant role in the immune response by regulating the expression of interferon and interferon-inducible genes, which are vital for the development and function of lymphocytes. IRF-4 is predominantly located in the nucleus of lymphoid cells, where IRF-4 acts as a transcriptional activator by binding to the interferon-stimulated response element (ISRE) of the major histocompatibility complex (MHC) class I promoter. Proper functioning of IRF-4 is essential for the immune system′s ability to respond to pathogens and maintain immune homeostasis, making IRF-4 a key player in both adaptive and innate immunity. Additionally, IRF-4 interacts with various proteins, including PU.1, which is important for the differentiation of B cells and T cells, further underscoring IRF-4′s significance in immune regulation. IRF-4 antibody (E-7) is an invaluable tool for researchers studying immune responses, lymphocyte development, and related pathologies.

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IRF-4 Antibody (E-7) References:

1. The role of IRF-4 in B and T cell activation and differentiation.  |  Pernis, AB. 2002. J Interferon Cytokine Res. 22: 111-20. PMID: 11846982
2. The role of IRF-4 in transcriptional regulation.  |  Marecki, S. and Fenton, MJ. 2002. J Interferon Cytokine Res. 22: 121-33. PMID: 11846983
3. IRF-4 activities in HTLV-I-induced T cell leukemogenesis.  |  Mamane, Y., et al. 2002. J Interferon Cytokine Res. 22: 135-43. PMID: 11846984
4. Identification of a novel GC-rich binding protein that binds to an indispensable element for constitutive IRF-4 promoter activity in B cells.  |  Nishiya, N., et al. 2004. Mol Immunol. 41: 855-61. PMID: 15261457
5. Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes.  |  Mamane, Y., et al. 2005. J Interferon Cytokine Res. 25: 43-51. PMID: 15684621
6. The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression.  |  Lossos, IS. 2007. Cancer Cell. 12: 189-91. PMID: 17785200
7. Downregulation of ZBTB24 hampers the G0/1- to S-phase cell-cycle transition via upregulating the expression of IRF-4 in human B cells.  |  Liang, J., et al. 2016. Genes Immun. 17: 276-82. PMID: 27098601
8. Effect of 50-Hz Magnetic Fields on Serum IL-1β and IL-23 and Expression of BLIMP-1, XBP-1, and IRF-4.  |  Molaei, S., et al. 2019. Inflammation. 42: 1800-1807. PMID: 31286334
9. Comparing IRF-4 Gene Expression Between Acute T cell- Mediated Rejection and Stable Renal Transplant Recipients.  |  Freidoon, M., et al. 2021. Iran J Kidney Dis. 15: 222-228. PMID: 33994382
10. IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury.  |  Chen, M., et al. 2021. Int Immunopharmacol. 100: 108142. PMID: 34555644

The preferred IRF-4 antibody is IRF-4 Antibody (F-4): sc-48338.