IRF-2 Antibody (TQ-5): sc-101069
- IRF-2 Antibody (TQ-5) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant IRF-2 of human origin
- recommended for detection of IRF-2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IRF-2 Antibody (TQ-5). This work is in progress.
IRF-2 Antibody (TQ-5) is a mouse monoclonal IgG2a antibody that detects IRF-2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IRF-2 plays a crucial role in the regulation of immune responses by acting as a transcriptional repressor of interferon regulatory factor-1, thereby modulating the expression of type I interferons and interferon-inducible genes. This regulatory function is vital for maintaining the balance between immune activation and suppression, which is essential for preventing excessive inflammation and autoimmunity. IRF-2 is primarily located in the nucleus, where IRF-2 binds to specific DNA sequences in the promoters of target genes, influencing their transcriptional activity. Understanding the cellular localization of IRF-2 highlights IRF-2′s role in gene regulation and potential impact on cellular responses to viral infections and other immune challenges. IRF-2 (TQ-5) monoclonal antibody serves as an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the pathophysiology of diseases associated with dysregulated interferon signaling.
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IRF-2 Antibody (TQ-5) References:
- Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression. | Blanco, JC., et al. 2000. J Exp Med. 191: 2131-44. PMID: 10859338
- IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms. | Minamino, K., et al. 2012. Int Immunol. 24: 573-81. PMID: 22773153
- Interferon regulatory factor (IRF)-1 and IRF-2 are associated with prognosis and tumor invasion in HCC. | Yi, Y., et al. 2013. Ann Surg Oncol. 20: 267-76. PMID: 22805863
- Prognostic value of IRF-2 expression in colorectal cancer. | Mei, Z., et al. 2017. Oncotarget. 8: 38969-38977. PMID: 28465494
- IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation. | Kawaguchi, M., et al. 2018. J Dermatol Sci. 90: 35-45. PMID: 29305258
- Expression of interferon regulatory factors (IRF-1 and IRF-2) during radiation-induced damage and regeneration of bone marrow by transplantation in mouse. | Ahamad, N. and Rath, PC. 2019. Mol Biol Rep. 46: 551-567. PMID: 30488374
- TRIM14 expression is regulated by IRF-1 and IRF-2. | Cui, J., et al. 2019. FEBS Open Bio. 9: 1413-1420. PMID: 31150153
- IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1. | Chen, YJ., et al. 2020. Dig Dis Sci. 65: 168-177. PMID: 31350707
- Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. | Yan, Y., et al. 2020. Cancer Immunol Immunother. 69: 1891-1903. PMID: 32377817
- IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer. | Chen, YJ., et al. 2022. J Transl Med. 20: 68. PMID: 35115027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRF-2 Antibody (TQ-5) | sc-101069 | 100 µg/ml | $339.00 |