IRF-1 Antibody (20): sc-135952
- IRF-1 Antibody (20) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 159-279 of IRF-1 of human origin
- recommended for detection of IRF-1 of human origin by WB and IP
- See IRF-1 (E-4): sc-514544 for IRF-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IRF-1 Antibody (20). This work is in progress.
IRF-1 Antibody (20) is a mouse monoclonal IgG1 antibody that detects interferon regulatory factor-1 (IRF-1) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Anti-IRF-1 antibody (20) recognizes a protein that plays a crucial role in the immune response by acting as a transcriptional activator for type I interferons, which are vital for the antiviral response and regulation of immune cell activity. IRF-1 is primarily located in the nucleus, where IRF-1 binds to specific DNA sequences in the promoters of interferon-α and interferon-β genes, thereby influencing their expression. IRF-1 (20) monoclonal antibody targets a protein essential for proper immune system functioning, as IRF-1 helps to initiate and sustain the antiviral state in cells. IRF-1′s interaction with IRF-2, which acts as a repressor, highlights the delicate balance of regulatory mechanisms that govern immune responses. The dynamic interplay between these two factors is critical, as overexpression of IRF-2 can lead to cell transformation, while increased levels of IRF-1 can reverse this effect, underscoring IRF-1′s importance in maintaining cellular homeostasis and immune integrity.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRF-1 Antibody (20) | sc-135952 | 50 µg/0.5 ml | $322.00 |