IRAK-1 Antibody (B-8): sc-515499
- IRAK-1 Antibody (B-8) is a mouse monoclonal IgG2a provided at 200 µg/ml
- specific for an epitope mapping between amino acids 692-712 at the C-terminus of IRAK-1 of human origin
- recommended for detection of IRAK-1 of human origin by WB, IP, IF and ELISA
- See IRAK-1 (F-4): sc-5288 for IRAK-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for IRAK-1 Antibody (B-8) for WB applications. This reagent is now offered in a bundle with IRAK-1 Antibody (B-8) (see ordering information below).
IRAK-1 Antibody (B-8) is a mouse monoclonal IgG2a antibody that detects IRAK-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRAK-1 plays a crucial role in the immune response by acting as a key mediator in the signaling pathways activated by interleukin-1 (IL-1) receptors. Upon IL-1 binding to its receptor, IRAK-1 is recruited to the receptor complex, leading to the activation of downstream signaling cascades, including the NF-kB pathway, which is essential for the transcription of pro-inflammatory cytokines. The proper functioning of IRAK-1 is vital for a robust immune response, and dysregulation of IRAK-1 has been implicated in various inflammatory diseases and conditions, highlighting IRAK-1′s importance as a therapeutic target. Additionally, IRAK-1 interacts with several other proteins, including TRAF6 and MyD88, which are critical for propagating the IL-1 signaling cascade. The ability of IRAK-1 to form complexes with these proteins underscores IRAK-1′s central role in mediating inflammatory responses and maintaining immune homeostasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRAK-1 Antibody (B-8) | sc-515499 | 200 µg/ml | $322.00 | |||
IRAK-1 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-541061 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRAK-1 (B-8) Neutralizing Peptide | sc-515499 P | 100 µg/0.5 ml | $69.00 |