IQGAP1 Antibody (D-3): sc-374307
- IQGAP1 Antibody (D-3) is a mouse monoclonal IgG1 λ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 314-422 mapping near the N-terminus of IQGAP1 of human origin
- Anti-IQGAP1 Antibody (D-3) is recommended for detection of IQGAP1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IQGAP1 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for IQGAP1 Antibody (D-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with IQGAP1 Antibody (D-3) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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IQGAP1 Antibody (D-3) is a mouse monoclonal IgG1 lambda light chain antibody targeting amino acids 314-422 near the N-terminus of IQGAP1, ensuring specific recognition across human, mouse, and rat samples in applications like western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IQGAP1, also known as IQ motif containing GTPase activating protein 1, is a key scaffold protein involved in regulating cellular structure and signaling. IQGAP1 interacts closely with small GTPases, such as Cdc42 and Rac1, to influence cell morphology, migration, and adhesion by controlling cytoskeletal reorganization. IQGAP1′s function is essential in cellular processes like proliferation and polarization, particularly in tissues like the placenta, lung, and kidney, where IQGAP1 localizes to the cytoskeleton and coordinates cellular responses. IQGAP1 also plays a critical role in cell-cell adhesion by binding to cadherin complex components, including E-cadherin, β-catenin, and α-catenin, thus promoting stability at cell junctions. This function is modulated by calmodulin in a calcium-dependent manner, which inhibits IQGAP1′s association with Cdc42, adding an additional layer of control over cellular dynamics. Available in both non-conjugated and conjugated forms, IQGAP1 (D-3) antibody is designed for reliable detection in diverse research applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IQGAP1 Antibody (D-3) | sc-374307 | 200 µg/ml | $322.00 | |||
IQGAP1 Antibody (D-3): m-IgGλ BP-HRP Bundle | sc-522695 | 200 µg Ab, 40 µg BP | $361.00 | |||
IQGAP1 Antibody (D-3) AC | sc-374307 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IQGAP1 Antibody (D-3) HRP | sc-374307 HRP | 200 µg/ml | $322.00 | |||
IQGAP1 Antibody (D-3) FITC | sc-374307 FITC | 200 µg/ml | $336.00 | |||
IQGAP1 Antibody (D-3) PE | sc-374307 PE | 200 µg/ml | $349.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 488 | sc-374307 AF488 | 200 µg/ml | $364.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 546 | sc-374307 AF546 | 200 µg/ml | $364.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 594 | sc-374307 AF594 | 200 µg/ml | $364.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 647 | sc-374307 AF647 | 200 µg/ml | $364.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 680 | sc-374307 AF680 | 200 µg/ml | $364.00 | |||
IQGAP1 Antibody (D-3) Alexa Fluor® 790 | sc-374307 AF790 | 200 µg/ml | $364.00 |