Integrin β5/ITGB5 Antibody (B-10): sc-390186

Integrin β5 Antibody (B-10) is a mouse monoclonal IgG2b antibody that detects Integrin β5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin β5 plays a crucial role in cell adhesion and signaling, functioning as a receptor that mediates interactions between cells and the extracellular matrix. Integrin β5 is primarily located on the cell surface, where anti-Integrin β5 antibody (B-10) can detect heterodimers formed with various α subunits, allowing binding to ligands such as fibronectin and vitronectin. Proper localization of Integrin β5 is essential for function, as Integrin β5 facilitates signal transmission from the extracellular environment to the cell interior, influencing processes such as cell migration, proliferation, and survival. Through engagement with the extracellular matrix, Integrin β5 supports structural integrity and activates intracellular signaling pathways vital for cellular responses to external stimuli. Integrin β5 monoclonal antibody (B-10) serves as an invaluable tool for researchers studying cell adhesion dynamics and intricate signaling networks governing cellular behavior in various biological contexts.

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Integrin β5/ITGB5 Antibody (B-10) References:

1. Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta5.  |  Wang, K., et al. 2000. J Virol. 74: 2731-9. PMID: 10684289
2. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.  |  Lane, NE., et al. 2005. J Bone Miner Res. 20: 58-66. PMID: 15619670
3. Lack of integrin β5 in Merkel cell carcinomas and derived cell lines is frequently associated with Merkel cell polyomavirus positivity.  |  Akgül, B., et al. 2012. J Dermatol Sci. 67: 66-8. PMID: 22503669
4. FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.  |  Liu, Y., et al. 2014. FEBS Lett. 588: 2859-66. PMID: 24997346
5. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.  |  Hu, J., et al. 2014. FEBS Lett. 588: 4348-56. PMID: 25448675
6. Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain.  |  Zeng, Q., et al. 2015. Biol Res. 48: 25. PMID: 25971622
7. Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis.  |  Wang, S., et al. 2016. Am J Cancer Res. 6: 1108-17. PMID: 27294003
8. Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis.  |  Zhang, Y., et al. 2022. Oncogene. 41: 2079-2094. PMID: 35181737
9. Dichotomous role of integrin-β5 in lung endothelial cells.  |  Blanchard, N., et al. 2022. Pulm Circ. 12: e12156. PMID: 36438452
10. Effects of Bushen Huoxue on integrin β3 and integrin β5 in the placental tissue of mice with repeated implantation failure caused by phospholipid antibodies.  |  Han, Y., et al. 2025. Technol Health Care. 33: 495-507. PMID: 39240601

The preferred Integrin β5/ITGB5 antibody is Integrin β5/ITGB5 Antibody (F-5): sc-398214.