Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420

Integrin β2 Antibody (CTB104) is a mouse monoclonal IgG2a kappa light chain antibody that detects Integrin β2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin β2 antibody (CTB104) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrin β2, also known as CD18, plays a crucial role in cell adhesion and signaling, functioning as a key component of integrin heterodimers that mediate interactions between cells and the extracellular matrix. Integrin β2 is primarily located on the cell surface, where Integrin β2 forms heterodimers with integrin α subunits, facilitating the binding of ligands such as fibronectin, collagen, and vitronectin. This binding is essential for various biological processes, including cell migration, immune response, and tissue repair. Proper localization of Integrin β2 at the cell membrane is vital for function, as such positioning allows for dynamic regulation of cell adhesion and signaling pathways that influence cellular behavior. Using Integrin β2 monoclonal antibody (CTB104) in research can provide insights into cell adhesion mechanisms and integrin roles in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin β2/ITGB2/CD18 Antibody (CTB104) References:

1. CD18 (leukocyte integrin beta2 subunit).  |  Cabañas, C. and Sánchez-Madrid, F. 1999. J Biol Regul Homeost Agents. 13: 137-9. PMID: 10503739
2. Human leukocytes contain a large pool of free forms of CD18.  |  Drbal, K., et al. 2000. Biochem Biophys Res Commun. 275: 295-9. PMID: 10964661
3. Monoclonal antibodies specific for bovine CD18.  |  Dusinský, R., et al. 2001. Folia Biol (Praha). 47: 108-10. PMID: 11409317
4. A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells.  |  Drbal, K., et al. 2001. Blood. 98: 1561-6. PMID: 11520808
5. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
6. β2 integrin activation and signal transduction in leukocyte recruitment.  |  Sun, H., et al. 2021. Am J Physiol Cell Physiol. 321: C308-C316. PMID: 34133240
7. The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia.  |  Bai, X., et al. 2024. Mol Ther. 32: 1510-1525. PMID: 38454605
8. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
9. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
10. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
11. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
12. Nomenclature and characterization of leukocyte differentiation antigens in ruminants.  |  Naessens, J., et al. 1997. Immunol Today. 18: 365-8. PMID: 9267076

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin β2/ITGB2/CD18 Antibody (CTB104) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin β2/ITGB2/CD18 Antibody (CTB104) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin β2/ITGB2/CD18 Antibody (CTB104) Specifications

Alternate Product Name: Integrin β2

Product Clone Name: CTB104

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-769

Epitope Target: Integrin β2

Epitope Species: human

Product Reactivity/Detection: Integrin β2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for Integrin β2/ITGB2/CD18 Antibody (CTB104): AC: Agarose, AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin