Integrin αX/ITGAX/CD11c Antibody (2Q865): sc-71455

Integrin αX Antibody (2Q865) is a mouse monoclonal IgG1 antibody that detects Integrin αX in human samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune response by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). Anti-Integrin αX antibody (2Q865) recognizes a protein essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, facilitating their migration to sites of inflammation, and promoting the phagocytosis of complement-coated particles. Proper functioning of Integrin αX is vital for effective immune surveillance and response, as abnormal expression is associated with hairy cell leukemia, highlighting significance in both normal physiology and disease states. Additionally, transcription of Integrin αX is regulated by various proteins and DNA elements, including Sp1, AP-1 family members, and PU.1, which underscores the complexity of expression and function in immune cells. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells can migrate from peripheral tissues to lymphoid organs, where they interact with T and B cells to initiate and modulate adaptive immune responses.

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Integrin αX/ITGAX/CD11c Antibody (2Q865) References:

1. c-Myc inhibits CD11a and CD11c leukocyte integrin promoters.  |  López-Rodríguez, C., et al. 2000. Eur J Immunol. 30: 2465-71. PMID: 11009078
2. CD11c+ cells are required for antigen-induced increase of mast cells in the lung.  |  Dahlin, JS., et al. 2012. J Immunol. 189: 3869-77. PMID: 22972929
3. CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.  |  Foster, GA., et al. 2015. J Immunol. 195: 5380-92. PMID: 26519532
4. Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.  |  Paterka, M., et al. 2016. EMBO J. 35: 89-101. PMID: 26612827
5. Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein.  |  Zeng, J., et al. 2018. J Immunol. 200: 3407-3419. PMID: 29626089
6. CD11c-MHC2low Macrophages Are a New Inflammatory and Dynamic Subset in Murine Adipose Tissue.  |  Wetzels, S., et al. 2020. Immunometabolism. 2: e200015. PMID: 34987865
7. The Transcription Factor RXRα in CD11c+ APCs Regulates Intestinal Immune Homeostasis and Inflammation.  |  Manoharan, I., et al. 2023. J Immunol. 211: 853-861. PMID: 37477694
8. Characterization of CD11c+ and DN2 B cells-an ongoing endeavor.  |  Bossuyt, X. 2024. J Allergy Clin Immunol. 153: 354. PMID: 37865899
9. Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages.  |  Nomaki, K., et al. 2024. Mol Brain. 17: 24. PMID: 38762724
10. B cell-intrinsic IFN-γ promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice.  |  Liu, S., et al. 2024. Cell Immunol. 405-406: 104883. PMID: 39503082

The preferred Integrin αX/ITGAX/CD11c antibody is Integrin αX/ITGAX/CD11c Antibody (B-6): sc-46676.