Integrin αV/β5/ITGB5/CD51 Antibody (P1F6): sc-81632

Integrin αV/β5 Antibody (P1F6) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the integrin αV and β5 subunits, also known as CD51 and CD61 respectively. Anti-Integrin αV/β5 antibody (P1F6) is raised against UCLA P3 cells of human origin and is recommended for the detection of Integrin αV and Integrin β5 in mouse, rat, and human samples using immunoprecipitation (IP) and immunofluorescence (IF) techniques. Integrin αVβ5, a heterodimeric protein, plays a crucial role in cell adhesion, migration, and signaling by interacting with extracellular matrix proteins such as vitronectin, fibronectin, and osteopontin. Additionally, Integrin αVβ5 interacts with intracellular proteins like talin and kindlin, which are essential for linking integrins to the actin cytoskeleton and facilitating signal transduction. This integrin functions as a receptor for various ligands, enabling processes such as angiogenesis, tumor metastasis, and immune cell regulation. Through clustering and binding to ligands, Integrin αVβ5 activates downstream signaling pathways that influence cell growth, differentiation, and apoptosis. Integrin αV/β5 monoclonal antibody (P1F6) serves as an essential tool for researchers studying the multifaceted roles of integrins in cellular physiology and pathology, providing reliable and reproducible results in diverse experimental settings.

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.