Integrin αV/ITGAV/CD51 Antibody (H-2): sc-376156

Integrin αV Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the Integrin αV subunit, also known as ITGAV or CD51. Integrin αV monoclonal antibody (H-2) specifically recognizes an epitope mapping between amino acids 859-888 at the C-terminus of human Integrin αV and is validated for detecting Integrin αV heavy chains in mouse, rat, and human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) assays. Integrin αV is a critical component of various integrin heterodimers that mediate cell adhesion, migration, and signal transduction by binding to extracellular matrix proteins such as vitronectin, fibronectin, and osteopontin. Integrin αV interacts with intracellular proteins like talin and kindlin, which are essential for linking integrins to the actin cytoskeleton and facilitating cellular responses to environmental cues. The function of Integrin αV is pivotal in processes including angiogenesis, tumor metastasis, and immune cell regulation, making Integrin αV a vital target for research in cancer biology, vascular biology, and immunology. By enabling the study of Integrin αV′s interactions and signaling pathways, anti-Integrin αV antibody (H-2) serves as an essential tool for researchers investigating the mechanisms of cell adhesion, migration, and signaling in various physiological and pathological contexts. The reliable performance of Integrin αV (H-2) antibody across multiple detection methods ensures reproducible and accurate results, supporting advancements in understanding Integrin αV′s role in cellular physiology and disease progression. Integrin αV monoclonal antibody (H-2) is indispensable for studies focused on the multifaceted roles of integrins in cellular behavior and therapeutic target validation.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αV/ITGAV/CD51 Antibody (H-2) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αV/ITGAV/CD51 Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αV/ITGAV/CD51 Antibody (H-2) Specifications

Alternate Product Name: Integrin αV

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 859-888

Epitope Target: Integrin αV

Epitope Species: human

Product Reactivity/Detection: Integrin αV heavy chain

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for Integrin αV/ITGAV/CD51 Antibody (H-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.