Integrin αV/ITGAV/CD51 Antibody (2Q888): sc-71451

Integrin αV Antibody (2Q888) is a mouse monoclonal IgG1 kappa light chain antibody raised against melanoma cells of human origin, designed for the detection of human Integrin αV by immunofluorescence (IF) and flow cytometry (FCM). Integrin αV, also known as CD51 or ITGAV, is a transmembrane glycoprotein that pairs with various β subunits (β1, β3, β5, β6, and β8) to form functional receptors involved in cell adhesion, migration, and signal transduction. Integrin αV undergoes crucial post-translational modifications, particularly N-linked glycosylation, which is essential for proper folding, stability, and ligand-binding affinity. Glycosylation of Integrin αV influences interaction with extracellular matrix proteins such as vitronectin, fibronectin, and osteopontin, thereby affecting cellular processes like angiogenesis, wound healing, and tumor progression. These post-translational modifications play a key role in modulating protein function and involvement in various physiological and pathological conditions, including cancer metastasis and inflammatory diseases. Anti-Integrin αV antibody (2Q888) recognizes both native and modified forms, serving as a valuable tool for researchers studying protein role and regulation in different cellular contexts. Understanding Integrin αV function, regulation, and post-translational modifications can provide insights into therapeutic targets for diseases where this protein plays a pivotal role.

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.