Integrin αV/ITGAV/CD51 Antibody (13C2): sc-53360

Integrin αV Antibody (13C2) is a mouse monoclonal IgG1 kappa light chain antibody raised against a cell suspension containing human osteoclasts, designed for the detection of human Integrin αV by flow cytometry (FCM). Integrin αV, also known as CD51 or ITGAV, is a transmembrane glycoprotein that pairs with multiple β subunits (β1, β3, β5, β6, and β8) to form various integrin receptors like αVβ3, αVβ5, αVβ6, and αVβ8, which are crucial for cell adhesion, migration, and signaling. Structurally, Integrin αV consists of a large extracellular domain featuring a β-propeller region and an I-like domain essential for ligand binding and interaction with β subunits, a single transmembrane helix, and a short cytoplasmic tail that connects to the cytoskeleton. This structural configuration allows Integrin αV to undergo conformational changes upon ligand binding, transmitting signals from the extracellular matrix (ECM) into the cell and influencing processes such as angiogenesis, bone resorption, and immune responses. The ability of Integrin αV to bind various ligands like vitronectin, fibronectin, and osteopontin underscores its role in mediating cell-ECM interactions and regulating cell behavior. Understanding the structure and function of Integrin αV is vital, as this protein plays a significant role in physiological and pathological conditions, including cancer progression, osteoporosis, and inflammatory diseases. Anti-Integrin αV antibody (13C2) serves as a valuable tool for researchers investigating the mechanisms involving Integrin αV and its associated pathways.

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.