Integrin αM/CD11b Antibody (LM2/1.6.11): sc-81721

Integrin αM Antibody (LM2/1.6.11) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize Integrin αM, also known as CD11b, ITGAM, Mac-1 α subunit, complement component receptor-3 α (CR3α), and macrophage antigen α polypeptide. Integrin αM is a critical heterodimeric cell adhesion molecule composed of the αM subunit paired with the β2 subunit, forming the Mac-1 or CR3 complex. This structural arrangement is essential for mediating interactions between immune cells and the extracellular matrix, facilitating processes like leukocyte adhesion, migration, and phagocytosis. Post-translational modifications of Integrin αM, including glycosylation, are vital for proper folding, stability, and binding affinity to ligands such as intracellular adhesion molecules (ICAMs), which are crucial for effective immune responses. Located on the surface of immune cells such as monocytes and macrophages, Integrin αM enables these cells to adhere to and traverse the endothelial barrier during inflammatory responses, as well as recognize and engulf pathogens through binding to complement-coated particles. Integrin αM monoclonal antibody (LM2/1.6.11) is validated for use in immunofluorescence (IF) and flow cytometry (FCM), making this reagent invaluable for researchers investigating immune cell functions, inflammatory mechanisms, and related pathological conditions. Anti-Integrin αM antibody (LM2/1.6.11) facilitates detailed studies into the molecular mechanisms underpinning immune responses, aiding in the development of therapeutic strategies for immune-mediated diseases.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.