Integrin αM/CD11b Antibody (CC125): sc-101830

Integrin αM Antibody (CC125) is a mouse monoclonal IgG1 antibody with a lambda light chain, expertly designed to target Integrin αM, also known as CD11b, ITGAM, MAC1A, MO1A, and complement component receptor-3 α (CR3α). Integrin αM is a vital cell surface glycoprotein located on the plasma membrane of leukocytes, where Integrin αM plays a crucial role in the immune response by mediating cell adhesion and migration. By binding to intracellular adhesion molecules (ICAMs) and other soluble ligands, Integrin αM forms a heterodimer with Integrin β2, creating the Mac-1 or CR3 complex, which is essential for the adherence of neutrophils and monocytes to the endothelium during inflammation. This interaction facilitates the phagocytosis of complement-coated pathogens, thereby enhancing the body′s ability to combat infections. Anti-Integrin αM antibody (CC125) is raised against thymocytes of bovine origin, ensuring robust reactivity with Integrin αM in both bovine and ovine species as demonstrated by flow cytometry (FCM) assays. The precise targeting capability of Integrin αM (CC125) antibody allows researchers to effectively study the localization and function of Integrin αM on the cell surface, providing valuable insights into immune cell behavior and inflammatory processes. Ideal for both basic research and diagnostic purposes, Integrin αM (CC125) monoclonal antibody is an indispensable tool for investigating the molecular mechanisms underlying immune responses and cellular interactions.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.