Integrin αM/CD11b Antibody (6A248): sc-71449

Integrin αM Antibody (6A248) is a mouse monoclonal IgG2a kappa light chain antibody designed to target Integrin αM, also known as CD11b, complement component receptor-3 α (CR3α), ITGAM, Mac-1 α subunit, and macrophage antigen α polypeptide. Integrin αM is a crucial cell adhesion molecule that plays a significant role in the immune system by mediating the adhesion and migration of leukocytes, particularly neutrophils and monocytes, to sites of inflammation. This integrin functions as part of the heterodimeric Integrin αMβ2 complex, commonly referred to as Mac-1 or CR3, which interacts with intracellular adhesion molecules (ICAMs) and other ligands to facilitate immune cell binding and communication. The ability of Integrin αM to bind to complement-coated particles is essential for the phagocytosis process, allowing immune cells to effectively engulf and eliminate pathogens and debris. Integrin αM monoclonal antibody (6A248) is specifically raised against peritoneal macrophages of rat origin, demonstrating affinity for Integrin αM in both mouse and rat species. Anti-Integrin αM antibody (6A248) is validated for multiple applications including immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM), making this tool valuable for researchers studying immune cell functions and related pathologies. By targeting Integrin αM, researchers can gain deeper insights into the mechanisms of immune cell adhesion, migration, and phagocytosis, which are pivotal for understanding inflammatory responses and developing therapeutic strategies for immune-related diseases.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.