Integrin αM/CD11b Antibody (2Q913): sc-71447

Integrin αM Antibody (2Q913) is a mouse monoclonal IgG2a kappa light chain antibody engineered to recognize Integrin αM, also known as CD11b, ITGAM, Mac-1 α subunit, and complement component receptor-3 α. Anti-Integrin αM antibody (2Q913) is raised against peritoneal macrophages of rat origin and demonstrates strong reactivity with Integrin αM from both mouse and rat species, making this reagent ideal for applications such as immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Integrin αM is a vital cell adhesion molecule that forms a heterodimer with Integrin β2 (CD18), creating the Mac-1 (Macrophage receptor 1) or CR3 (complement receptor 3) complex. This complex interacts with various proteins, including intracellular adhesion molecules (ICAM-1, ICAM-2, ICAM-3), inactivated complement component iC3b, and fibrinogen, facilitating essential processes such as leukocyte adhesion, migration, and phagocytosis of opsonized particles. The interactions between Integrin αM and these binding partners are crucial for effective immune responses, including the recruitment of neutrophils and monocytes to sites of inflammation and the clearance of pathogens. Understanding these protein-protein interactions is essential for elucidating the mechanisms underlying immune cell trafficking, inflammation, and host defense. Integrin αM (2Q913) monoclonal antibody provides researchers with a reliable tool to study these interactions, enabling detailed investigations into the molecular pathways that govern immune cell behavior and the development of therapeutic strategies targeting inflammatory and immune-related diseases. Anti-Integrin αM antibody (2Q913) is an indispensable reagent for scientists aiming to explore the complex network of interactions involving Integrin αM, thereby contributing to advancements in immunology and the treatment of various pathological conditions.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.