Integrin αL/ITGAL/CD11a Antibody (38): sc-7306

Integrin αL Antibody (38) is a mouse monoclonal IgG2a antibody that detects Integrin αL in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin αL, also called CD11a, is a crucial component of the immune system, primarily expressed on leukocytes, where anti-Integrin αL antibody (38) plays a vital role in mediating cell adhesion and migration. Integrin αL is essential for the immune response, facilitating interaction between leukocytes and endothelial cells during inflammation, allowing immune cells to exit the bloodstream and reach sites of infection or injury. The structure of Integrin αL, which consists of a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail, enables conformational changes necessary for activation and function. These structural features allow Integrin αL to bind to ligands, such as intercellular adhesion molecules (ICAMs), effectively promoting leukocyte adhesion and migration. The ability of Integrin αL to interact with various ligands is critical for maintaining immune surveillance and responding to pathological conditions, making Integrin αL a key target for therapeutic interventions in inflammatory diseases. Integrin αL monoclonal antibody (38) serves as an invaluable tool for researchers studying immune cell dynamics and the underlying mechanisms of immune responses.

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Integrin αL/ITGAL/CD11a Antibody (38) References:

1. RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements.  |  Puig-Kröger, A., et al. 2003. Blood. 102: 3252-61. PMID: 12855590
2. RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters.  |  Domínguez-Soto, A., et al. 2005. Immunobiology. 210: 133-9. PMID: 16164020
3. Effects of CD70 and CD11a in immune thrombocytopenia patients.  |  Ma, L., et al. 2011. J Clin Immunol. 31: 632-42. PMID: 21541792
4. CD11a polymorphisms regulate TH2 cell homing and TH2-related disease.  |  Knight, JM., et al. 2014. J Allergy Clin Immunol. 133: 189-97.e1-8. PMID: 23726040
5. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.  |  Jiang, E., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 34-43. PMID: 24158516
6. CD11a is essential for normal development of hematopoietic intermediates.  |  Bose, TO., et al. 2014. J Immunol. 193: 2863-72. PMID: 25108025
7. Expression of CD11a in lymphocyte subpopulation in immune thrombocytopenia.  |  Liu, YX., et al. 2015. Int J Clin Exp Pathol. 8: 15642-51. PMID: 26884833
8. Possible Role of CD11a in Primary Immune Thrombocytopenia Patients on Immunosuppressive Therapy.  |  Abdel Hameed, MR., et al. 2021. J Blood Med. 12: 197-205. PMID: 33790683
9. CD11a regulates hematopoietic stem and progenitor cells.  |  Hou, L. and Yuki, K. 2023. Front Immunol. 14: 1219953. PMID: 37781399
10. Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 αL integrin.  |  Cai, C., et al. 2025. J Virol. 99: e0123524. PMID: 39804090

The preferred Integrin αL/ITGAL/CD11a antibody is Integrin αL/ITGAL/CD11a Antibody (E-1): sc-374172.