Integrin α6/ITGA6/CD49f Antibody (1.BB.460): sc-71426

Integrin α6 Antibody (1.BB.460) is a mouse monoclonal IgG2b antibody raised against the SW1222 colorectal cell line of human origin. Anti-Integrin α6 antibody (1.BB.460) recognizes Integrin α6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α6, also known as CD49f, is a transmembrane glycoprotein that pairs with β1 or β4 integrin subunits to form receptors for laminin, a major component of the basement membrane. By mediating cell adhesion to the extracellular matrix, Integrin α6 plays a critical role in cellular processes such as proliferation, migration, differentiation, and survival. These functions are essential in normal physiological processes like wound healing and embryonic development, as well as in pathological conditions including cancer metastasis and tumor progression. As a signaling receptor, Integrin α6 can influence intracellular pathways that regulate gene expression and cytoskeletal organization, particularly in epithelial cells where α6β4 integrins contribute to hemidesmosome formation. Given its broad involvement in vital cellular activities, studying Integrin α6 is important for understanding disease mechanisms and developing therapeutic strategies. Integrin α6 monoclonal antibody (1.BB.460) allows for specific detection and analysis of Integrin α6, facilitating research in areas such as oncology, developmental biology, and cell biology.

The preferred Integrin α6/ITGA6/CD49f antibody is Integrin α6/ITGA6/CD49f Antibody (GOH3): sc-19622.