Integrin α5/ITGA5/CD49e Antibody (JBS5): sc-59762

Integrin α5 Antibody (JBS5) is a mouse monoclonal IgG1 antibody that recognizes Integrin α5 in human and canine samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α5 plays a crucial role in cell adhesion and is primarily located on the cell surface, where anti-Integrin α5 antibody (JBS5) detects heterodimers formed with the β1 subunit to create the α5β1 integrin receptor. This receptor is essential for binding to extracellular matrix components like fibronectin, which is vital for various cellular processes, including tissue repair and development. Integrin α5 on the cell surface facilitates the attachment of cells to the extracellular matrix, promoting cell migration and proliferation, which are critical during wound healing and embryogenesis. Furthermore, Integrin α5 interaction with fibronectin not only stabilizes cell adhesion but also initiates intracellular signaling pathways that influence cell behavior, making Integrin α5 a key player in maintaining tissue integrity and regulating cellular responses to environmental cues. Integrin α5 (JBS5) monoclonal antibody serves as an invaluable tool for researchers studying these fundamental processes in both human and canine models.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Integrin α5/ITGA5/CD49e Antibody (JBS5) References:

1. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.  |  Kuwada, SK., et al. 2005. J Biol Chem. 280: 19027-35. PMID: 15757908
2. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity.  |  Choi, S., et al. 2009. Blood. 113: 1845-55. PMID: 19036703
3. Segmental assembly of fibronectin matrix requires rap1b and integrin α5.  |  Lackner, S., et al. 2013. Dev Dyn. 242: 122-31. PMID: 23192979
4. Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.  |  Hang, Q., et al. 2015. J Biol Chem. 290: 29345-60. PMID: 26483551
5. Integrin α5 promotes tumor progression and is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma.  |  Xie, JJ., et al. 2016. Hum Pathol. 48: 69-75. PMID: 26772401
6. 16 kDa vasoinhibin binds to integrin alpha5 beta1 on endothelial cells to induce apoptosis.  |  Morohoshi, K., et al. 2018. Endocr Connect. 7: 630-636. PMID: 29622663
7. Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis.  |  Uetaki, M., et al. 2022. Mol Biol Cell. 33: ar78. PMID: 35704469
8. γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5.  |  Chen, W., et al. 2023. Toxicol Lett. 383: 177-191. PMID: 37392970
9. Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway.  |  Li, W., et al. 2023. Animal Model Exp Med. 6: 573-584. PMID: 37565509
10. Integrin-α5 expression and its role in non-small cell lung cancer progression.  |  Ka, M., et al. 2024. Cancer Sci.. PMID: 39581761

The preferred Integrin α5/ITGA5/CD49e antibody is Integrin α5/ITGA5/CD49e Antibody (P1D6): sc-13547.