Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2): sc-7019

Integrin α3 Antibody (Ralph 3.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin α3 of rat origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α3 (Ralph 3.2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrins, which are heterodimers formed from noncovalently associated transmembrane α and β subunits, play a crucial role in cell adhesion and signaling. The Integrin α3 chain, also referred to as very late activation antigen 3 (VLA-3), undergoes post-translational modifications, including cleavage in the extracellular domain, resulting in disulfide-linked light and heavy chains that associate with β1 to form a functional integrin complex. This modification enhances Integrin α3′s ability to interact with various extracellular matrix proteins, facilitating essential biological processes such as cell migration, differentiation, and survival. Integrin α3′s capacity to bind ligands like fibronectin and collagen underscores its importance in maintaining tissue integrity and mediating cellular responses to the extracellular environment. Using anti-Integrin α3 antibody (Ralph 3.2) in research can provide valuable insights into the dynamic roles of integrins in cellular functions and their implications in various physiological and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) References:

1. Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3).  |  Tsuji, T., et al. 2002. Clin Exp Metastasis. 19: 127-34. PMID: 11964076
2. The PPFLMLLKGSTR motif in globular domain 3 of the human laminin-5 alpha3 chain is crucial for integrin alpha3beta1 binding and cell adhesion.  |  Kim, JM., et al. 2005. Exp Cell Res. 304: 317-27. PMID: 15707596
3. Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior.  |  Kerrisk, ME., et al. 2013. J Neurosci. 33: 6742-52. PMID: 23595732
4. Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion.  |  Nakada, M., et al. 2013. Br J Cancer. 108: 2516-24. PMID: 23652300
5. A human integrin-α3 mutation confers major renal developmental defects.  |  Shukrun, R., et al. 2014. PLoS One. 9: e90879. PMID: 24621570
6. Tetraspanin 8-rictor-integrin α3 complex is required for glioma cell migration.  |  Pan, SJ., et al. 2015. Int J Mol Sci. 16: 5363-74. PMID: 25761241
7. Absence of the Integrin α3 Subunit Induces an Activated Phenotype in Human Keratinocytes.  |  Pazzagli, C., et al. 2017. J Invest Dermatol. 137: 1387-1391. PMID: 28163067
8. Emerging Laminin-332‒Dependent and ‒Independent Roles for Integrin α3 in Protumorigenic Signaling.  |  Li, M. and Iden, S. 2021. J Invest Dermatol. 141: 713-716. PMID: 33752808
9. Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression.  |  Zhou, J., et al. 2022. Cell Death Dis. 13: 486. PMID: 35597804
10. Integrin α3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2.  |  Yao, J. and Wang, L. 2023. Curr Protein Pept Sci. 24: 247-256. PMID: 36843258

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) Specifications

Alternate Product Name: Integrin α3

Product Clone Name: Ralph 3.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin α3

Epitope Species: rat

Product Reactivity/Detection: Integrin α3

Species Reactivity/Detection: rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.