Integrin α3/ITGA3/CD49c Antibody (P1B5): sc-13545

Integrin α3 Antibody (P1B5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin α3 of human origin by immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Integrin α3 antibody (P1B5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Integrins are heterodimers formed from noncovalently associated transmembrane α and β subunits, playing a crucial role in cell adhesion and signaling. Integrin α3 chain, also referred to as very late activation antigen 3 (VLA-3), undergoes post-translational modifications, including cleavage in the extracellular domain, resulting in disulfide-linked light and heavy chains that associate with β1 to form a functional integrin complex. This modification enhances Integrin α3′s ability to interact with various extracellular matrix proteins, such as fibronectin and collagen, facilitating essential cellular processes like migration, differentiation, and survival. Integrin α3′s binding to these ligands is vital for maintaining tissue integrity and mediating cellular responses to the extracellular environment, making Integrin α3 an important target for research in cell biology and therapeutic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α3/ITGA3/CD49c Antibody (P1B5) References:

1. Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth.  |  Hamano, Y. and Kalluri, R. 2005. Biochem Biophys Res Commun. 333: 292-8. PMID: 15979458
2. Multiple roles of integrin-α3 at the neuromuscular junction.  |  Ross, JA., et al. 2017. J Cell Sci. 130: 1772-1784. PMID: 28386022
3. Blockade of integrin α3 attenuates human pancreatic cancer via inhibition of EGFR signalling.  |  Lee, J., et al. 2019. Sci Rep. 9: 2793. PMID: 30808960
4. Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer.  |  Ke, FY., et al. 2020. Cancer Sci. 111: 3478-3492. PMID: 32648337
5. Integrin α3 negative podocytes: A gene expression study.  |  Frommherz, LH., et al. 2022. Matrix Biol Plus. 16: 100119. PMID: 36060790
6. Expression of type VI collagen α3 chain in canine mammary carcinomas.  |  Araki, M., et al. 2023. Res Vet Sci. 159: 171-182. PMID: 37148736
7. Integrin α3 promotes TH17 cell polarization and extravasation during autoimmune neuroinflammation.  |  Park, E., et al. 2023. Sci Immunol. 8: eadg7597. PMID: 37831759
8. Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.  |  Liu, L., et al. 2024. CNS Neurosci Ther. 30: e14498. PMID: 37867481
9. Targeting Integrin α3 Blocks β1 Maturation, Triggers Endoplasmic Reticulum Stress, and Sensitizes Glioblastoma Cells to TRAIL-Mediated Apoptosis.  |  Kuranaga, Y., et al. 2024. Cells. 13: PMID: 38727288
10. Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis.  |  White, MJV., et al. 2024. Sci Rep. 14: 21623. PMID: 39284829

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α3/ITGA3/CD49c Antibody (P1B5) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α3/ITGA3/CD49c Antibody (P1B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α3/ITGA3/CD49c Antibody (P1B5) Specifications

Alternate Product Name: Integrin α3

Product Clone Name: P1B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin α3

Epitope Species: human

Product Reactivity/Detection: Integrin α3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for Integrin α3/ITGA3/CD49c Antibody (P1B5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.