Integrin α3/ITGA3/CD49c Antibody (E-8): sc-393298

Integrin α3 Antibody (E-8) is a mouse monoclonal IgG2b antibody that detects Integrin α3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin α3, also known as very late activation antigen 3 (VLA-3), very common antigen 2 (VCA-2), extracellular matrix receptor 1 (ECMR1), and galactoprotein b3 (GAPB3), plays a crucial role in cell adhesion and signaling, which are vital for various biological processes including cell growth, differentiation, migration, and apoptosis. Integrin α3 is primarily located on the cell surface, where anti-Integrin α3 antibody (E-8) recognizes heterodimers with β1 subunits, allowing interaction with components of the extracellular matrix such as fibronectin and collagen. Proper localization of Integrin α3 is essential for function, as Integrin α3 facilitates communication between cells and their environment, influencing cellular responses to external stimuli. Additionally, Integrin α3 undergoes post-translational modifications, including cleavage in the extracellular domain, which results in the formation of disulfide-linked light and heavy chains that enhance interaction with extracellular matrix proteins. Integrin α3′s ability to cluster and bind ligands is critical for the activation of integrin-mediated signaling pathways, making Integrin α3 a key player in maintaining tissue integrity and facilitating cellular responses during physiological and pathological processes.

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Integrin α3/ITGA3/CD49c Antibody (E-8) References:

1. Integrin alpha3 expression as a prognostic factor in colon cancer: association with MRP-1/CD9 and KAI1/CD82.  |  Hashida, H., et al. 2002. Int J Cancer. 97: 518-25. PMID: 11802216
2. RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1.  |  Adereth, Y., et al. 2005. Nat Cell Biol. 7: 1240-7. PMID: 16273094
3. Integrin alpha3 subunit participates in myoblast adhesion and fusion in vitro.  |  Brzóska, E., et al. 2006. Differentiation. 74: 105-18. PMID: 16533309
4. Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma.  |  Kurokawa, A., et al. 2008. Cancer. 112: 1272-81. PMID: 18224668
5. Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex.  |  Dallaire, F., et al. 2009. J Virol. 83: 5329-38. PMID: 19297475
6. CD151 promotes proliferation and migration of PC3 cells via the formation of CD151-integrin α3/α6 complex.  |  Yang, W., et al. 2012. J Huazhong Univ Sci Technolog Med Sci. 32: 383-388. PMID: 22684562
7. Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.  |  Makarov, A., et al. 2013. Cell Biol Int. 37: 1080-8. PMID: 23686814
8. High Expression of Integrin α3 Predicts Poor Prognosis and Promotes Tumor Metastasis and Angiogenesis by Activating the c-Src/Extracellular Signal-Regulated Protein Kinase/Focal Adhesion Kinase Signaling Pathway in Cervical Cancer.  |  Du, Q., et al. 2020. Front Oncol. 10: 36. PMID: 32117712
9. Regulation of proteins in the VLA cell substrate adhesion family: influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression.  |  Fingerman, E. and Hemler, ME. 1988. Exp Cell Res. 177: 132-42. PMID: 3292271
10. Isolation and characterization of laminin-10/11 secreted by human lung carcinoma cells. laminin-10/11 mediates cell adhesion through integrin alpha3 beta1.  |  Kikkawa, Y., et al. 1998. J Biol Chem. 273: 15854-9. PMID: 9624186

The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.