Integrin α3/ITGA3/CD49c Antibody (A-6): sc-393290

Integrin α3 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects Integrin α3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin α3, also known as very late activation antigen 3 (VLA-3), very common antigen 2 (VCA-2), extracellular matrix receptor 1 (ECMR1), and galactoprotein b3 (GAPB3), plays a crucial role in cell adhesion and signaling, which are vital for various biological processes including cell growth, differentiation, migration, and apoptosis. Integrin α3 is primarily located on the cell surface, where anti-Integrin α3 antibody (A-6) can detect heterodimers formed with β1 subunits, allowing interaction with components of the extracellular matrix such as fibronectin and collagen. Proper localization of Integrin α3 is essential for function, as Integrin α3 facilitates communication between cells and their environment, influencing cellular responses to external stimuli. Additionally, Integrin α3 undergoes post-translational modifications, including cleavage in the extracellular domain, which results in the formation of disulfide-linked light and heavy chains that enhance interaction with extracellular matrix proteins. The ability of Integrin α3 to cluster and bind ligands is critical for the activation of integrin-mediated signaling pathways, making Integrin α3 a key player in maintaining tissue integrity and facilitating cellular responses during physiological and pathological processes. Integrin α3 monoclonal antibody (A-6) serves as an invaluable tool for researchers studying the dynamics of cell adhesion and signaling in human tissues.

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Integrin α3/ITGA3/CD49c Antibody (A-6) References:

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6. Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers.  |  Takada, Y., et al. 1988. J Cell Biochem. 37: 385-93. PMID: 2458366
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The preferred Integrin α3/ITGA3/CD49c antibody is Integrin α3/ITGA3/CD49c Antibody (A-3): sc-374242.