INSM1 Antibody (C-1): sc-377428
- INSM1 Antibody (C-1) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 97-135 within an internal region of INSM1 of human origin
- recommended for detection of INSM1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- TransCruz reagent for ChIP application (sc-377428 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for INSM1 Antibody (C-1) for WB applications. This reagent is now offered in a bundle with INSM1 Antibody (C-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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INSM1 Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects INSM1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). INSM1, also known as insulinoma-associated protein 1 or zinc finger protein IA-1, is a crucial transcription factor that plays a significant role in neuroendocrine differentiation, particularly during embryonic development. INSM1 is primarily localized in the nucleus, where INSM1 regulates gene expression essential for the formation of neuroendocrine tissues. INSM1 (C-1) antibody serves as a valuable marker for cancer research since INSM1 is not found in normal adult tissues but is highly expressed in neuroendocrine tumors. Structurally, INSM1 features five Cys(2)-His(2)-type zinc finger DNA binding domains, which facilitate interaction with specific DNA sequences, allowing INSM1 to act as a transcriptional repressor of the Neuro D promoter. Additionally, INSM1 recruits cyclin D1 as a co-repressor, underscoring INSM1′s role in the regulation of cell cycle progression and differentiation. The gene encoding INSM1 is directly regulated by Neurogenin 3, which binds to the INSM1 promoter region and induces transcription, highlighting the intricate network of regulatory mechanisms that govern neuroendocrine development. Anti-INSM1 antibody (C-1) is an essential tool for researchers investigating the molecular pathways involved in neuroendocrine differentiation and tumorigenesis.
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INSM1 Antibody (C-1) References:
- Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation. | Lan, MS. and Breslin, MB. 2009. FASEB J. 23: 2024-33. PMID: 19246490
- Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function. | Jia, S., et al. 2015. EMBO J. 34: 1417-33. PMID: 25828096
- INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma. | Chen, C., et al. 2015. Oncotarget. 6: 36700-12. PMID: 26456864
- Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass. | Tao, W., et al. 2018. Diabetes. 67: 2615-2625. PMID: 30257979
- Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers. | Staaf, J., et al. 2020. Arch Pathol Lab Med. 144: 1075-1085. PMID: 31913660
- Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors. | Mahalakshmi, B., et al. 2020. Cell Oncol (Dordr). 43: 367-376. PMID: 32219703
- INSM1 immunostaining in solid papillary carcinoma of the breast. | Kudo, N., et al. 2021. Pathol Int. 71: 51-59. PMID: 33156579
- Diagnostic Utility of INSM1 in Medullary Thyroid Carcinoma. | Seok, JY., et al. 2021. Int J Surg Pathol. 29: 615-626. PMID: 33650906
- INSM1 Expression in Mesenchymal Tumors and Its Clinicopathological Significance. | Zhang, Q., et al. 2022. Biomed Res Int. 2022: 1580410. PMID: 36531655
- INSM1 promotes breast carcinogenesis by regulating C-MYC. | Guan, Y., et al. 2023. Am J Cancer Res. 13: 3500-3516. PMID: 37693125
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INSM1 Antibody (C-1) | sc-377428 | 200 µg/ml | $322.00 | |||
INSM1 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-552157 | 200 µg Ab; 40 µg BP | $361.00 | |||
INSM1 (C-1) Neutralizing Peptide | sc-377428 P | 100 µg/0.5 ml | $69.00 | |||
INSM1 Antibody (C-1) X | sc-377428 X | 200 µg/0.1 ml | $322.00 |