INPP1 Antibody (F-9): sc-393584
- INPP1 Antibody (F-9) is a mouse monoclonal IgG1 κ INPP1 antibody provided at 200 µg/ml
- raised against amino acids 1-72 mapping at the N-terminus of INPP1 of human origin
- INPP1 Antibody (F-9) is recommended for detection of INPP1 of human origin by WB, IP, IF and ELISA
- Anti-INPP1 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for INPP1 Antibody (F-9) for WB applications. These reagents are now offered in bundles with INPP1 Antibody (F-9) (see ordering information below).
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INPP1 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects INPP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). INPP1 (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. INPP1, or inositol polyphosphate 1-phosphatase, plays a crucial role in cellular signaling by hydrolyzing inositol phosphates, which are vital for numerous cellular processes such as neuronal survival and signal transduction from growth factors, neurotransmitters, and G protein-coupled receptors. This 399 amino acid protein is widely expressed, with highest levels found in pancreas and kidney, and is a key player in phosphatidylinositol signaling pathway. By removing phosphate group at position one of inositol ring from polyphosphates like inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate, INPP1 modulates various physiological responses, including those related to cardiac function. Notably, overexpression of INPP1 has been linked to reduced responses to atrial natriuretic peptide and myosin light chain 2, which are associated with contraction-induced hypertrophy. Furthermore, defects in INPP1 have been implicated in neurodevelopmental disorders such as autism and manic-depressive illness, highlighting its importance in both cellular function and human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
INPP1 Antibody (F-9) References:
- Transcription of the inositol polyphosphate 1-phosphatase gene (INPP1) is upregulated in human colorectal cancer. | Li, SR., et al. 2000. Mol Carcinog. 27: 322-9. PMID: 10747296
- Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). | Løvlie, R., et al. 1999. Pharmacogenetics. 9: 517-28. PMID: 10780272
- Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. | Piccardi, MP., et al. 2002. Psychiatr Genet. 12: 23-7. PMID: 11901356
- Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. | Woodcock, EA., et al. 2002. J Biol Chem. 277: 22734-42. PMID: 11932254
- Lithium long-term treatment in mood disorders: clinical and genetic predictors. | Serretti, A. 2002. Pharmacogenomics. 3: 117-29. PMID: 11966408
- Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. | Serajee, FJ., et al. 2003. J Med Genet. 40: e119. PMID: 14627686
- Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. | Michelon, L., et al. 2006. Neurosci Lett. 403: 288-93. PMID: 16787706
- Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene. | Okabe, I. and Nussbaum, RL. 1995. Genomics. 30: 358-60. PMID: 8586440
- The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness. | Steen, VM., et al. 1998. Pharmacogenetics. 8: 259-68. PMID: 9682271
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INPP1 Antibody (F-9) | sc-393584 | 200 µg/ml | $316.00 | |||
INPP1 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-527695 | 200 µg Ab; 10 µg BP | $354.00 | |||
INPP1 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-533068 | 200 µg Ab; 20 µg BP | $354.00 | |||
INPP1 Antibody (F-9) AC | sc-393584 AC | 500 µg/ml, 25% agarose | $416.00 | |||
INPP1 Antibody (F-9) HRP | sc-393584 HRP | 200 µg/ml | $316.00 | |||
INPP1 Antibody (F-9) FITC | sc-393584 FITC | 200 µg/ml | $330.00 | |||
INPP1 Antibody (F-9) PE | sc-393584 PE | 200 µg/ml | $343.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 488 | sc-393584 AF488 | 200 µg/ml | $357.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 546 | sc-393584 AF546 | 200 µg/ml | $357.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 594 | sc-393584 AF594 | 200 µg/ml | $357.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 647 | sc-393584 AF647 | 200 µg/ml | $357.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 680 | sc-393584 AF680 | 200 µg/ml | $357.00 | |||
INPP1 Antibody (F-9) Alexa Fluor® 790 | sc-393584 AF790 | 200 µg/ml | $357.00 |