Ini1 Antibody (F-4): sc-166164
- Ini1 Antibody (F-4) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of Ini1 of human origin
- recommended for detection of Ini1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-166164 X, 200 µg/0.1 ml)
- See Ini1 (A-5): sc-166165 for Ini1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Ini1 Antibody (F-4) for WB and IHC(P) applications. These reagents are now offered in bundles with Ini1 Antibody (F-4) (see ordering information below).
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Ini1 Antibody (F-4) is a mouse monoclonal IgG2a antibody that detects Ini1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ini1, also known as integrase interactor 1 or SNF5, plays a crucial role in the SWI-SNF chromatin remodeling complex, which is essential for the regulation of gene expression by altering nucleosome structure in an ATP-dependent manner. anti-Ini1 antibody (F-4) helps researchers study how Ini1 stabilizes the assembly of other core subunits, such as Brm and Brg-1, thereby enhancing the remodeling activity necessary for transcriptional activation. Ini1 is implicated in various cellular processes, including differentiation and development, and Ini1 dysfunction has been associated with several cancers, highlighting its importance in maintaining normal cellular function and genomic integrity. Ini1 (F-4) antibody serves as an invaluable tool for researchers studying chromatin dynamics and gene regulation, providing insights into the molecular mechanisms underlying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ini1 Antibody (F-4) References:
- Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. | Roberts, CW., et al. 2000. Proc Natl Acad Sci U S A. 97: 13796-800. PMID: 11095756
- Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1. | Yung, E., et al. 2001. Nat Med. 7: 920-6. PMID: 11479624
- The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription. | Ariumi, Y., et al. 2006. Retrovirology. 3: 47. PMID: 16889668
- Integrase interactor 1 (Ini1/hSNF5) is a repressor of basal human immunodeficiency virus type 1 promoter activity. | Boese, A., et al. 2009. J Gen Virol. 90: 2503-2512. PMID: 19515827
- Integrase interactor 1 regulates proliferation, apoptosis and invasion in gastric cancer cells. | Wang, XC., et al. 2012. Chin Med J (Engl). 125: 527-32. PMID: 22490415
- Integrase interactor 1 in health and disease. | Das, S. 2015. Curr Protein Pept Sci. 16: 478-90. PMID: 25772157
- Comparative molecular genetic analysis of simian and human HIV-1 integrase interactor INI1/SMARCB1/SNF5. | Pyeon, D., et al. 2015. Arch Virol. 160: 3085-91. PMID: 26350979
- SNF5 is Involved in Suppression of Hepatocellular Carcinoma Progression via TGF-Beta 1 Signaling. | Sun, H., et al. 2016. Anat Rec (Hoboken). 299: 869-77. PMID: 27111394
- Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer. | Ho, KC., et al. 2020. Diagnostics (Basel). 10: PMID: 32380731
- Clinical Diagnosis and Treatment Analyses on SMARCB1 (Integrase Interactor 1)-Deficient Sinonasal Carcinoma: Case Series with Systematic Review of the Literature. | Wang, R., et al. 2022. World Neurosurg. 161: e229-e243. PMID: 35123020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ini1 Antibody (F-4) | sc-166164 | 200 µg/ml | $322.00 | |||
Ini1 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-540033 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ini1 Antibody (F-4): m-IgG2a BP-HRP Bundle | sc-546839 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ini1 Antibody (F-4) X | sc-166164 X | 200 µg/0.1 ml | $322.00 |