Inhibin β-A Antibody (E-1): sc-166503

Inhibin β-A Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Inhibin beta-A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Inhibin beta-A antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Inhibin beta-A protein plays a crucial role in regulating reproductive hormones, particularly in inhibiting follicle-stimulating hormone (FSH) secretion from the pituitary gland, which is vital for maintaining proper reproductive function and hormonal balance. Inhibin beta-A protein is predominantly expressed in the liver, uterus, and ovaries, where Inhibin beta-A protein participates in various physiological processes, including germ cell development and maturation, as well as erythroid differentiation. The balance between inhibins and activins is essential, as inhibins suppress FSH release while activins promote FSH release, thus influencing reproductive health and development. Inhibin beta-A protein is part of the transforming growth factor beta (TGFβ) superfamily, which encompasses a wide range of growth and differentiation factors that are integral to embryonic development and adult tissue homeostasis. Understanding Inhibin beta-A protein function and regulation is important for elucidating its role in reproductive biology and potential implications in fertility treatments and hormonal therapies.

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Inhibin β-A Antibody (E-1) References:

1. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
2. Multiple type-beta transforming growth factors and their receptors.  |  Massagué, J., et al. 1987. J Cell Physiol Suppl. Suppl 5: 43-7. PMID: 2890647
3. Inhibin A-subunit cDNAs from porcine ovary and human placenta.  |  Mayo, KE., et al. 1986. Proc Natl Acad Sci U S A. 83: 5849-53. PMID: 3016724
4. Inhibin, beta A regulates the transforming growth factor-beta pathway to promote malignant biological behaviour in colorectal cancer.  |  He, Z., et al. 2021. Cell Biochem Funct. 39: 258-266. PMID: 32662905
5. Inhibin β-A (INHBA) induces epithelial-mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway.  |  Yu, Y., et al. 2021. Bioengineered. 12: 4681-4696. PMID: 34346300
6. Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A.  |  Wu, M., et al. 2022. BMC Complement Med Ther. 22: 110. PMID: 35439976
7. Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging.  |  Kawagishi-Hotta, M., et al. 2022. J Dermatol Sci. 106: 150-158. PMID: 35610160
8. Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas.  |  Staudacher, JJ., et al. 2022. BMC Cancer. 22: 953. PMID: 36064338
9. Human inhibin genes. Genomic characterisation and sequencing.  |  Stewart, AG., et al. 1986. FEBS Lett. 206: 329-34. PMID: 3758355
10. Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation.  |  Albano, RM., et al. 1993. Development. 117: 711-23. PMID: 8330535
11. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.  |  Schmitt, J., et al. 1996. Genomics. 32: 358-66. PMID: 8838799
12. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Inhibin β-A Antibody (E-1) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-Inhibin β-A Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Inhibin β-A Antibody (E-1) Specifications

Alternate Product Name: INHBA

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 307-426

Epitope Target: Inhibin β-A

Epitope Species: human

Product Reactivity/Detection: precursor and mature Inhibin β-A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Inhibin β-A Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin