ING1 Antibody (E-10): sc-373817
- ING1 Antibody (E-10) is a mouse monoclonal IgG1 κ ING1 antibody provided at 200 µg/ml
- raised against amino acids 331-442 mapping at the C-terminus of ING1 of human origin
- ING1 Antibody (E-10) is recommended for detection of ING1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ING1 Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ING1 Antibody (E-10) for WB applications. These reagents are now offered in bundles with ING1 Antibody (E-10) (see ordering information below).
ING1 Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ING1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ING1 Antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ING1, or Inhibitor of Growth Protein 1, is a crucial 422 amino acid protein encoded by the human gene ING1, belonging to the ING family and characterized by a PHD-type zinc finger. ING1 plays a significant role in regulating cell growth by cooperating with tumor suppressor p53/TP53, thereby modulating p53-dependent transcriptional activation, which is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. ING1 is primarily located in the nucleus, where ING1 exerts its functions, and exists in several isoforms, including p47ING1, p33ING1, and p24ING1, each with distinct expression patterns across various tissues. p33ING1 isoform is ubiquitously expressed in all normal tissues, while p24ING1 is specifically found in the testis, liver, and kidney, with limited expression in the colon and brain, highlighting ING1′s diverse roles in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ING1 Antibody (E-10) References:
- Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. | Tachibana, M., et al. 2004. Int J Oncol. 25: 913-20. PMID: 15375540
- Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. | Goeman, F., et al. 2005. Mol Cell Biol. 25: 422-31. PMID: 15601862
- A functional link between the tumour suppressors ARF and p33ING1. | González, L., et al. 2006. Oncogene. 25: 5173-9. PMID: 16607280
- [Expression of P33ING1, P53 and their relationship with apoptosis in anal canal carcinoma]. | Chen, LS., et al. 2006. Zhonghua Wei Chang Wai Ke Za Zhi. 9: 338-41. PMID: 16886119
- ING1 and ING2: multifaceted tumor suppressor genes. | Guérillon, C., et al. 2013. Cell Mol Life Sci. 70: 3753-72. PMID: 23412501
- CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. | Rusu, AD., et al. 2021. Open Biol. 11: 210077. PMID: 34493070
- ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat. | Yang, Y., et al. 2023. Eur J Cell Biol. 102: 151341. PMID: 37459799
- Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. | Garkavtsev, I., et al. 1996. Nat Genet. 14: 415-20. PMID: 8944021
- Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). | Garkavtsev, I., et al. 1997. Cytogenet Cell Genet. 76: 176-8. PMID: 9186514
- Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34. | Zeremski, M., et al. 1997. Somat Cell Mol Genet. 23: 233-6. PMID: 9330636
- Tumor suppressors. Teaming up to restrain cancer. | Oren, M. 1998. Nature. 391: 233-4. PMID: 9440684
- The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. | Garkavtsev, I., et al. 1998. Nature. 391: 295-8. PMID: 9440695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ING1 Antibody (E-10) | sc-373817 | 200 µg/ml | $322.00 | |||
ING1 Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-527416 | 200 µg Ab; 10 µg BP | $361.00 | |||
ING1 Antibody (E-10): m-IgG1 BP-HRP Bundle | sc-532789 | 200 µg Ab; 20 µg BP | $361.00 | |||
ING1 Antibody (E-10) AC | sc-373817 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ING1 Antibody (E-10) HRP | sc-373817 HRP | 200 µg/ml | $322.00 | |||
ING1 Antibody (E-10) FITC | sc-373817 FITC | 200 µg/ml | $336.00 | |||
ING1 Antibody (E-10) PE | sc-373817 PE | 200 µg/ml | $349.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 488 | sc-373817 AF488 | 200 µg/ml | $364.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 546 | sc-373817 AF546 | 200 µg/ml | $364.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 594 | sc-373817 AF594 | 200 µg/ml | $364.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 647 | sc-373817 AF647 | 200 µg/ml | $364.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 680 | sc-373817 AF680 | 200 µg/ml | $364.00 | |||
ING1 Antibody (E-10) Alexa Fluor® 790 | sc-373817 AF790 | 200 µg/ml | $364.00 |