p33ING1 Antibody (CAb 3): sc-21728

p33ING1 Antibody (CAb 3) is a mouse monoclonal IgG1 kappa light chain antibody that detects p33ING1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p33ING1 Antibody (CAb 3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p33ING1 protein, which is 422 amino acids in length and encoded by the human gene ING1, plays a crucial role in regulating cell growth and apoptosis. As a member of the ING family, p33ING1 contains a PHD-type zinc finger that is essential for interaction with tumor suppressor protein p53/TP53, thereby modulating p53-dependent transcriptional activation. This interaction is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which is a hallmark of cancer. p33ING1 isoform is ubiquitously expressed across normal tissues, while other isoforms, such as p24ING1, show tissue-specific expression patterns, highlighting p33ING1′s importance in various biological processes. anti-p33ING1 antibody (CAb 3) in multiple formats allows for versatile applications in research, facilitating the study of its role in cancer biology and other cellular functions.

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p33ING1 Antibody (CAb 3) References:

1. p33(ING1) enhances UVB-induced apoptosis in melanoma cells.  |  Cheung, KJ. and Li, G. 2002. Exp Cell Res. 279: 291-8. PMID: 12243754
2. Expression of p33ING1 mRNA and chemosensitivity in brain tumor cells.  |  Tallen, G., et al. 2003. Anticancer Res. 23: 1631-5. PMID: 12820433
3. Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.  |  Goeman, F., et al. 2005. Mol Cell Biol. 25: 422-31. PMID: 15601862
4. A functional link between the tumour suppressors ARF and p33ING1.  |  González, L., et al. 2006. Oncogene. 25: 5173-9. PMID: 16607280
5. The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.  |  Fegers, I., et al. 2007. J Proteome Res. 6: 4182-8. PMID: 17929852
6. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.  |  Li, N., et al. 2012. Cell Death Dis. 3: e283. PMID: 22419112
7. mRNA and protein of p33ING1 in normal and cancer tissues.  |  Zhao, S. and Zheng, HC. 2020. Transl Cancer Res. 9: 3623-3633. PMID: 35117725
8. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.  |  Garkavtsev, I., et al. 1996. Nat Genet. 14: 415-20. PMID: 8944021
9. Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1).  |  Garkavtsev, I., et al. 1997. Cytogenet Cell Genet. 76: 176-8. PMID: 9186514
10. Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.  |  Zeremski, M., et al. 1997. Somat Cell Mol Genet. 23: 233-6. PMID: 9330636
11. Tumor suppressors. Teaming up to restrain cancer.  |  Oren, M. 1998. Nature. 391: 233-4. PMID: 9440684
12. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.  |  Garkavtsev, I., et al. 1998. Nature. 391: 295-8. PMID: 9440695

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p33ING1 Antibody (CAb 3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-p33ING1 Antibody (CAb 3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p33ING1 Antibody (CAb 3) Specifications

Alternate Product Name: p33ING1

Product Clone Name: CAb 3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: ING1

Epitope Species: human

Product Reactivity/Detection: p33ING1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for p33ING1 Antibody (CAb 3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin