Importin-7 Antibody (C-10): sc-515165

Importin-7 Antibody (C-10) is a mouse monoclonal IgG3 antibody that detects Importin-7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Importin-7, also known as Ran-binding protein 7 or RanBP7, is a crucial 1,038 amino acid protein encoded by the human gene IPO7, belonging to the importin β family and characterized by its single importin N-terminal domain. anti-Importin-7 antibody (C-10) plays a vital role in studying nuclear protein import, where Importin-7 functions either as an autonomous nuclear transport receptor or as an adapter-like protein in conjunction with the Importin β subunit KPNB1. Importin-7 serves as a receptor for nuclear localization signals (NLS), facilitating the translocation of import substrates through the nuclear pore complex (NPC) via an energy-dependent, Ran-mediated mechanism. Upon reaching the nucleoplasmic side of the NPC, Importin-7 binds to Ran, leading to the dissociation of the Importin-7/substrate complex, after which Importin-7 is re-exported to the cytoplasm, where GTP hydrolysis releases Ran. Importin-7 is predominantly expressed in the nucleus and is found in most tissues, underscoring its essential role in cellular transport processes. Importin-7 monoclonal antibody (C-10) is an invaluable tool for researchers studying nuclear transport mechanisms and related cellular functions.

The preferred Importin-7 antibody is Importin-7 Antibody (E-2): sc-365231.